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Determination of deuteration rate of iodomethane-d3 using quantitative proton nuclear magnetic resonance WANG Yu-liang, WAN Xin-huan, ZHANG Yun-yun, XIAO Tong, LI Fu-wei, GAO Hong-Mei, LIU Gui-juan, LIN Yun-liang Shandong Science    2021, 34 (5): 136-142.   DOI: 10.3976/j.issn.1002-4026.2021.05.017 Abstract （3408）      PDF（pc） （1173KB）（3891）       Knowledge map    In this study, a quantitative proton nuclear magnetic resonance (qHNMR) method was proposed to determine the deuteration rate of iodomethane-d3.An experiment was conducted on a 400 MHz spectrometer using dimethyl terephthalate (DMT) and dimethyl sulfoxide (DMSO-d6) as the internal standard reference and deuterated solvent, respectively. The following parameters were set: spectral width 4807.69 Hz, transmitter frequency offset 2000.65 Hz, relaxation delay time 65 s, and number of scans 16 times. The peak of δ2.16 in iodomethane-d2 and that of δ8.07 in dimethyl terephthalate were considered as the quantitative and internal standard peaks, respectively. The methodological assessment of linearity, precision, repeatability, stability, and durability was performed, and good results were achieved. The proposed qHNMR method can be used for determining the deuteration rate of iodomethane-d3. This method is accurate, reliable, simple, and fast and does not require its own reference substance. Thus, it can meet the test requirements of iodomethane-d3 deuteration rate in the laboratory. Reference | Related Articles | Metrics

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A Cyber-Physical System LIU Xiang-Zhi, LIU Xiao-Jian, WANG Zhi-Xue, CHENG Wei, LI Jian-Xin J4    2010, 23 (3): 56-61.   Abstract （2799）      PDF（pc） （792KB）（8487）       Knowledge map    Related Articles | Metrics Cited: Baidu(15)

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Development and application of ocean data buoy technology in China WANG Jun-cheng, LI Yun-zhou Shandong Science    2019, 32 (5): 1-20.   DOI: 10.3976/j.issn.1002-4026.2019.05.001 Abstract （2666）      PDF（pc） （15404KB）（651）       Knowledge map    Ocean data buoy are important technical means for obtaining offshore in-situ environmental parameters such as hydrology and meteorology,and play an important role in marine environmental monitoring,early warning and forecasting,disaster prevention and mitigation,resource development,and maritime traffic. In this paper, the effect, composition, classification, main theory and technology system of ocean data buoy are summarized. The paper presents the development of domestic ocean data buoy in history and an overview of technological breakthrough in recent years. It also introduces the composition and application of marine monitoring network in China and compares the technology of ocean data buoy in China with and that in more advanced countries. Finally, the development trends of ocean data buoy and buoy monitoring network are expected. Reference | Related Articles | Metrics

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Fast determination of maize starch content in cornflour YU Lu-Hao, YANG Jun-Hui, MENG Qing-Jun, YANG Yan, MA Yao-Hong J4    2012, 25 (1): 19-23.   DOI: 10.3976/j.issn.1002-4026.2012.01.005 Abstract （2480）      PDF（pc） （1053KB）（4000）       Knowledge map            This paper employs phenol-sulfuric acid, DNS and reducing sugar analyzer methods to determine the starch content in cornflour. We comprehensively compare their operation processes and the acquired data. Results show that reducing sugar analyzer method can determine maize starch content more conveniently and rapidly. Related Articles | Metrics Cited: Baidu(12)

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Research on nutrient components of different species of Chaenomeles speciosa Nakal ZHANG Heng, GENG Yan-Ling, WANG Dai-Jie, LIU Jian-Hua, WANG Xiao, DU Jin-Hua, LI Sheng-Bo J4    2011, 24 (2): 24-27.   Abstract （2453）      PDF（pc） （977KB）（2413）       Knowledge map             We determined and analyzed protein,total sugar,total acid,pectin, vitamin,amino acids,inorganic salt and mineral elements of 14 species of Chaenomeles speciosa Nakal. The content of their total sugar is in the range of 1.3~3.5 g/100 g; the content of their amino acid is rich and can reach 0.26 g/100 g~0.50 g/100 g; the content of their vitamin C is in the range of 68.8~159.3 mg/100 g, significantly higher than other common fruits. The content of their mineral elements is richhigher kalium and lower sodium. The content of these nutrient components in Jinbao is significantly superior to the other species. Experimental results show the content of nutrient components of Chaenomeles speciosa Nakal is rich and these fruits are worth being explored and utilized, especially for Jinbao. Related Articles | Metrics

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Toxicity of aspirin to gastrointestinal tract of zebrafish SUN Chen, HE Qiu-xia, HAN Li-wen, CHEN Xi-qiang, WANG Xi-min, CHU Jie, HAN Jian, WANG Rong-chun, HOU Hai-rong, LIU Ke-chun SHANDONG SCIENCE    2016, 29 (6): 50-55.   DOI: 10.3976/j.issn.1002-4026.2016.06.008 Abstract （2325）      PDF（pc） （5989KB）（1082）       Knowledge map    We performed a preliminary analysis of gastrointestinal toxicity of aspirin through analysis of peristalsis, detection of secretion functionality of gastrointestinal endothelial cells and histomorphology of intestinal mucosa with zebrafish as animal model. We discover that aspirin concentration of 50 μg/mL can improve the peristalsis. Aspirin concentration of 50 μg/mL or 100 μg/mL will impair secretion functionality of goblet cells on intestinal mucosa though routine HE staining among intestinal mucosa does not change. Reference | Related Articles | Metrics

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Nutritional ingredients analysis of four kinds of jujubes LI Gao-yan,SUN Zhao-qian,GUO Qing-mei,ZHOU Feng-qin SHANDONG SCIENCE    2017, 30 (3): 33-38.   DOI: 10.3976/j.issn.1002-4026.2017.03.007 Abstract （2323）      PDF（pc） （910KB）（1142）       Knowledge map    The nutritional ingredients such as general nutrients, amino acids, minerals, total triterpene, cAMP and flavonoids of Zhanhua winter jujube, Laoling zizyphus jujube, Xinjiang jujube and Quanchenghong jujube were analyzed, respectively. The results indicated that there were 17 amino acids in each of the four kinds of jujubes, 7 amino acids were essential to human life among them, and the four kinds of jujubes were also rich in minerals such as Ca, Na, Mg, K, Fe, Zn, Se, Sr, Cu. For Xinjiang jujube, the soluble solids content 36.50%, the soluble polysaccharide content 31.49%, vitamin C content 1 018.00 mg /100 g and the content of cAMP 26.17 mg /100 g were all higher than the other three jujubes. The content of total triterpene of Quanchenghong jujube was the highest, which was 74.26 mg/100 g; The crude fiber content of Laoling zizyphus jujube was the highest, which amounted to 2.85 g/100 g; The total flavone content of Zhanhua jujube was the highest, which was 404.28 mg/100 g. The contents of different nutrient among different kinds of jujubes are different, which show their different development potential in the medicinal value and commercial production. Reference | Related Articles | Metrics

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Research on coal mine cloud connection platform of fiber internet of things HOU Pei-Hu, FU Xiao-Ning, WANG Ying, CHENG Zhi-Yong, NI Jia-Sheng, LIU Tong-Yu, WANG Hong-Chun J4    2011, 24 (2): 41-46.   Abstract （2261）      PDF（pc） （1373KB）（2258）       Knowledge map           We originally propose and design a universal interface for fiber internet of things in view of the issue of difficult fiber sensors fusion in a fiber sensor system in coal mine safety detection. We also construct a cloud connection platform for fiber internet of things with photoelectronic detection, embedded electronics and communications technology. Many optic fiber sensors can be communicated and fused by this platform, so we can construct a coal mine internet of things to improve the level of coal mine safety detection. Related Articles | Metrics Cited: Baidu(1)

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Fully Cycle Extendability of a Triangularly Connected［4,2］-Graphs WANG Lei, WANG Jiang-Lu J4    2010, 23 (6): 13-15.   Abstract （2261）      PDF（pc） （725KB）（1855）       Knowledge map              A graph G is a ［s,t］-graph, if the included subgraphs of its any s vertices have at least t edges.This paper proves that G is either fullcycle extendable or isomorphic to graph F if G is a triangularly connected［4,2］graph without any isolated vertex.Graph F has an induced subgraph isomorphic to K3∨K2. Related Articles | Metrics

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Research on negative impacts of vitrification of Salvia miltiorrhiza Bge.f.alba plantlets QI Cui-Ying, WANG Ning, LI Xu-Xia, WANG Feng-Xiang, LI Feng-Sheng, ZHU Fu-You J4    2012, 25 (4): 32-35.   DOI: 10.3976/j.issn.1002-4026.2012.04.008 Abstract （2244）      PDF（pc） （1141KB）（2116）       Knowledge map              This paper addresses the impacts of different culture conditions on the vitrification of Salvia miltiorrhiza Bge.f.alba seedlings. We investigated the influences of KT/NAA ratio, active carbon and agar concentration on the prevention of vitrification of tissue culture seedlings with the tender stems of Salvia miltiorrhiza Bge. f.alba C.Y. Wu et H.W.Li.‘ buyu’ as the explants and MS as basic medium. Experimental results show that the tissue culture seedlings has higher bud multiplication coefficient and lower vitrification rate when KT concentration of 1.5 mg·L-1, NAA concentration of 0.5 mg·L-1, active carbon of 0.3% and agar concentration of 0.8% are employed. Therefore, the MS+KT 1.5 mg·L-1 +NAA 0.5 mg·L-1 + agar 0. 8% +active carbon 0.3% medium can effectively prevent vitrification of plantlets. Related Articles | Metrics

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Comprehensive Development and Applications of Microalgae LI Yan, ZHOU Wen-Guang, ZHANG Xiao-Dong, SUN Li J4    2010, 23 (4): 84-87.   Abstract （2215）      PDF（pc） （784KB）（3813）       Knowledge map    Related Articles | Metrics Cited: Baidu(5)

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Significance and research advances of directional solidification of magnesium alloys TANG Shou-Qiu, ZHOU Ji-Xue, TIAN Chang-Wen, LI Wei-Hong, YANG Yuan-Sheng J4    2011, 24 (4): 18-22.   Abstract （2204）      PDF（pc） （1872KB）（2792）       Knowledge map           Directional solidification of Magnesium alloys, an advanced preparation and solidification technology, has great potentialities and significance. This paper presents its development necessity, research and application advances, and  future development tendency. Reference | Related Articles | Metrics Cited: Baidu(2)

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Content determination of total polysaccharides in leaves of Pyrus  betulaefolia Bge. from different processing methods WANG Shao-Jie, ZHANG Ling-Lian, XU Ling-Chuan, LIU Yu-Hong, JIANG Hai-Qiang J4    2011, 24 (4): 15-17.   Abstract （2201）      PDF（pc） （1036KB）（1861）       Knowledge map             We determined polysaccharides content of two manufactures from the leaves of Pyrus betulaefolia Bge. using phenolvitriol method.With the contrast, glucose, we measured their absorbency at the wavelength of 490 nm. A good linear relationship exists between the absorbency and the determined content in the range of 0.01968 ～0.0984 mg. Recovery experiment indicates that the average recovery rate is 99.02 % (n=5) and that RSD is 3.34 %. Determination results of total polysaccharide contents from different processes are 7.82% for that prepared by the traditional process of drying by sun and dewing in night and 5.27% for that prepared by sunbaked till to red after humidity accumulation. Experimental results show that the content of total polysaccharide in the leaves of P. betulaefolia Bge. is high. It can therefore be utilized as a total polysaccharide rich medical resource. Reference | Related Articles | Metrics

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Mechanism design and kinematics analysis of a four axis stacking robot SUN Jie, LI Qian, LIU Guang-Liang, GE Zhao-Bin, LI Xiang-Dong J4    2011, 24 (1): 97-101.   Abstract （2201）      PDF（pc） （855KB）（3523）       Knowledge map                We design a fouraxis balance hoist based palletizing robot to satisfy the requirement of logistics automation to robot palletizer. We analyze the kinematic characteristics for the arms of the robot and further obtain an optimal equation of its linkage mechanism. Experimental results show that such a robot can satisfy the requirement of logistics automation. Related Articles | Metrics

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Research Advances of Natural Products Antiangiogenesis CHEN Xi-Qiang, HOU Hai-Rong, LIU Ke-Chun, WANG Xi-Min, WANG Si-Feng, HE Qiu-Xia J4    2010, 23 (6): 34-38.   Abstract （2111）      PDF（pc） （735KB）（2734）       Knowledge map             Anti-angiogenesis therapy has become an important anti-cancer approach. This paper classifies such recently reported natural products of antitumor neovascularization as terpenoids, phenols, flavonoids, alkaloids, anthraquinones, etc. This paper also surveys some fruits on tumor angiogenesis suppression of natural products in order to provide some new ideas for the development of Chinese antitumor drugs. Related Articles | Metrics

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A robot tool frame calibration method LIU Cheng-Ye, LI Wen-Guang, MA Shi-Guo, ZHI Jian-Bin, LIU Guang-Liang, WU Hao J4    2012, 25 (1): 69-74.   DOI: 10.3976/j.issn.1002-4026.2012.01.015 Abstract （2085）      PDF（pc） （1377KB）（4483）       Knowledge map            We present a simple and effective calibration method for robot tool frame calibration. This method is based on the kinematic computation of a stacking robot, and recognizes the relative position of the tool frame to the end of the robot without the aid of extra measurement equipment. The method then recognizes the orientation of the robot tool frame based on the derived relative position. This method only employs the linear least square algorithm, so it is easy to be realized. We employ MATLAB and Virtual Robot Simulator to simulate the proposed method. Results show that the method is feasible and can be applied to practical environments to reduce the offline time and improve the level of automation. Related Articles | Metrics Cited: Baidu(7)

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Research advances of nutrient sensors in marine monitoring WANG Hong-Liang, GAO Yang, CHENG Tong-Lei, LIN Guo-Xing, MA Ran J4    2011, 24 (3): 32-36.   Abstract （2083）      PDF（pc） （1018KB）（2428）       Knowledge map           Nutrients are necessary substance basis for the growth of marine phytoplankton. Determining their marine distributions has significant meanings in understanding global geochemical cycles and forecasting the occurrence of HABs (Harmful algal blooms). Online nutrient sensors have been greatly improved during the past decades. This paper surveys their research advances in marine monitoring, introduces and compares their detection principles, ranges and limits, and presents their technical bottlenecks and development tendency. Related Articles | Metrics Cited: Baidu(1)

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Jacobi method for eigenvalues calculation XU Zheng-Wen, YIN Qing-Li Shandong Science    2011, 24 (6): 19-21.   DOI: 10.3976/j.issn.1002-4026.2011.06.006 Abstract （2056）      PDF（pc） （1083KB）（3002）       Knowledge map    This paper addresses classical Jacobi method of eigenvalues calculation of a real symmetric matrix. It converts a real symmetric matrix into a diagonal matrix by a series of orthogonal similarity transformations, and then derives all eigenvalues and their corresponding eigenvectors. The paper presents the formulas of all orthogonal transformations, which are implemented by MATLAB programming. This provides a simple and practical calculation tool for the computation of practical problems. Related Articles | Metrics

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The Preparation of  Gold Nanoparticles Modified Innobilized Glucose Oxidase Membranes BI Chun-Yuan, ZHOU Mo-Li, DIAO Xiao-Hua, SHU Sai-Rong, SHI Jian-Guo, CUI Jing-Cheng, CHEN Hao, GUO Chang-Miao, FENG Kai, SU Bing, CHEN Xiao J4    2010, 23 (2): 14-17.   Abstract （2052）      PDF（pc） （896KB）（3188）       Knowledge map    Related Articles | Metrics

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Sensitivity analysis of the quality evaluation model of honeysuckle CHENG Wei, LI Ke, WANG Zhi-Xue, LI Shu-Bin, HOU En-Guang, GAO Yan, WANG Liang, LIU Qing, ZHAO Bo-Nian, YU Zong-Yuan J4    2011, 24 (5): 5-9.   Abstract （2044）      PDF（pc） （1000KB）（1673）       Knowledge map          This paper performs sensitivity analysis of the quality evaluation model for honeysuckle. This quantitatively shows the influences of the variation of every common peak in the chromatography fingerprint atlas of crude medicine on pharmacological efficacy (antibacerial rate). This analysis provides a new and referential method for the quality evaluation of traditional Chinese herbal medicine. Reference | Related Articles | Metrics

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The disinfection effect of ozone water on soil-borne pathogenic fungi LI Hong-mei, WEI Yan-li, HU Jin-dong, YANG Kai, LIU Bao-jun, YANG He-tong, LI Ji-shun Shandong Science    2021, 34 (4): 67-72.   DOI: 10.3976/j.issn.1002-4026.2021.04.011 Abstract （2039）      PDF（pc） （2168KB）（911）       Knowledge map    For exploring the green methods of soil disinfection, the disinfection effects of ozone water at different mass concentrations on three soil-borne pathogenic fungi, Fusarium oxysporum, Rhizoctonia solani, and Botrytis cinerea, were studied. The results showed that ozone water in the mass concentration range of 1.0~5.0 mg/L has certain sterilizing effect on the spores of the three pathogenic fungi. The mass concentration of ozone water is the main factor affecting the sterilization rate, whereas the treatment time has no significant effect on it. Increasing the mass concentration of ozone water and the frequency of irrigation can significantly enhance the sterilization rate of the three pathogenic fungi in the soil. Irrigation of the soil with ozone water can significantly reduce disease incidence in plants. However, it leads to growth inhibition, and the introduction of Trichoderma can eliminate this inhibition. Reference | Related Articles | Metrics

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Surface-Enhanced Raman Spectrum of Dye Molecules in Nanoparticle Systems MA Qiu-Mei, WANG Yan-Wei, JIAO Zhuo-Feng, DAN Shi-Yong, YANG Guang-Can J4    2010, 23 (2): 28-32.   Abstract （2037）      PDF（pc） （1153KB）（3063）       Knowledge map    Related Articles | Metrics

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Analysis and Control of Flocculent Sediments in Rose Water MA Yao-Hong, MENG Qing-Jun, ZHANG Li-Qun, LU Hua, TANG Hua J4    2010, 23 (4): 31-35.   Abstract （2035）      PDF（pc） （1206KB）（2804）       Knowledge map    Related Articles | Metrics

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Research Advances of Chemical Constituents and Analysis Method of Forsythia suspense DUAN Wen-Juan, GENG Yan-Ling, CHU He, LIN Yun-Liang, WANG Xiao, LIU Jian-Hua J4    2010, 23 (2): 33-37.   Abstract （2030）      PDF（pc） （835KB）（5186）       Knowledge map    Related Articles | Metrics Cited: Baidu(27)

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New method for isolation and culture of lichenized fungi QIU Zhen-Lu, WANG Hai-Ying, ZHAO Zun-Tian J4    2011, 24 (1): 33-35.   Abstract （2000）      PDF（pc） （716KB）（2005）       Knowledge map             This paper presented a new method for isolation and culture of lichenized fungi and lichen endophyte fungi. We directly selected medulla mycelium for cultivation with PDA nutrition medium. The growth rate of the community of lichenized fungi was 80.43%, while the contamination rate was only 7.14% under the conditions of nutrition medium of 25℃ and 14 days later. The superiority of this method was therefore simplicity, highefficiency and low contamination rate. Related Articles | Metrics Cited: Baidu(1)

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CFD based flow field analysis of a seabed monitoring platform LIU Jie, TUN Cheng-Xuan, LV Bin, LI Zheng-Bao J4    2012, 25 (1): 65-68.   DOI: 10.3976/j.issn.1002-4026.2012.01.014 Abstract （1997）      PDF（pc） （1881KB）（2344）       Knowledge map           We employed computational fluid dynamics (CFD) to numerically simulate the flow field surrounding a seabed monitoring platform. We also employed a software, FLUENT, to construct a CFD model for the flow field, and performed its mesh division and determination of its boundary conditions based on the external structure of the seabed monitoring platform. We further analyzed the numerical simulated results of the velocity and pressure field of the outside sea current of the platform. This research can provide a reference for the structure design and improvement of a seabed monitoring platform, and can lay foundation for the thorough research. Related Articles | Metrics Cited: Baidu(3)

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Construction of Shandong coastal monitoring buoy network DU Li-Bin, WU Cheng-Xuan, HE Hai-Qing, QU Jun-Le J4    2011, 24 (1): 1-5.   Abstract （1992）      PDF（pc） （947KB）（2623）       Knowledge map             We construct a coastal monitoring buoy network based on the Shandong specific coastal geographic environment. It covers such area as distant sea, offshore and coast and extends from coast to 60 miles away from coast. We also perform its optimization. It can detect ocean pollution, red tide, sea water quality, and effectively monitor storm tide and typhoon. Related Articles | Metrics Cited: Baidu(3)

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Prevention and control strategies of COVID-19 based on theory of principle, method and prescription of Treatise on Febrile Diseases WANG Feng-xia, ZHANG Yun, LIU Ke-chun Shandong Science    2020, 33 (2): 12-16.   DOI: 10.3976/j.issn.1002-4026.2020.02.002 Abstract （1992）      PDF（pc） （1077KB）（521）       Knowledge map    Based on the theory of principle, method and prescription of Treatise on Febrile Diseases written by Zhang Zhongjing, we analyzed the etiology and pathogenesis of COVID-19(corona virus disease 2019) that is currently prevalent. Reasonable diagnosis and treatment suggestions for prevention and control were proposed. 2019-nCoV is regard as a kind of typhoid virus, and COVID-19 should be defined as what Zhongjing called typhoid, a kind of cold-induced disorders. It is not suitable for the febrile patients infected by 2019-nCoV who are afraid of cold to cool down or diminish inflammation by intravenous fluids. The study could provide valuable guidance for the prevention and control for not only the COVID-19, but also the similar epidemic infectious diseases in the future. Reference | Related Articles | Metrics

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Isolation and identification of three Chinese new records in Trichoderma harzianum species complex ZHANG Guangzhi，ZHANG Xinjian，CHEN Quan，LI Zhe，GUO Kai，YANG Hetong SHANDONG SCIENCE    2015, 28 (6): 43-46.   DOI: 10.3976/j.issn.1002-4026.2015.06.007 Abstract （1977）      PDF（pc） （1694KB）（2803）       Knowledge map    We isolated three Trichoderma strains, Z19, CX584 and CY3585, from soils of Tibet, Shandong and Yunnan by selective medium THSM. These strains were identified by ITS rDNA and TEF1α sequences and morphological characteristics. Results show that the three Trichoderma strains were Trichoderma harzianum species complex,T. afroharzianum, T. atrobrunneum and T. simmonsii. These three species are all new record to China. Reference | Related Articles | Metrics Cited: Baidu(2)

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Research advances of biodiesel green production techniques JIN Fu-Qiang, LI Yan, WANG Jian-Mei, HU Su-Qin, CAI Fei-Peng, LIU Qiang J4    2011, 24 (2): 61-64.   Abstract （1974）      PDF（pc） （969KB）（2871）       Knowledge map            This paper surveys some biodiesel production techniques. We emphasize the green production technique of biodiesel. It includes heterogeneous catalyzed transesterification, supercritical fluid process, hydrodeoxygenation and its refining process oriented vacuum distillation, molecular distillation, supercritical fluid extractionfractionation, microfiliration membrane separation and ionexchange absorption. We also give some predictions on the development tendencies of biodiesel. Related Articles | Metrics Cited: Baidu(2)

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Effects of Nd and B combined addition on microstructure and mechanical properties of AZ91 magnesium alloy ZHAO De-Gang, TIAN Chang-Wen, LIU Yun-Teng, JIANG Li-Kun, ZHAN Cheng-Wei J4    2011, 24 (4): 23-27.   Abstract （1966）      PDF（pc） （1752KB）（1787）       Knowledge map            This paper presents the effects of B and Nd combined addition on microstructure and mechanical properties of AZ91 alloy. SEM results show that B and Nd combined addition significantly refines the grain size of α-Mg and β-Mg17Al12  precipitates. Grain refinement is due to the presence of AlB2 particles, nucleants for Mg grains, and Nd addition refines β-Mg17Al12 phases.  Al2Nd and Mg12Nd exist on the intermetallic surface. They have high thermal stability and significantly improve mechanical properties of magnesium alloys. Normal temperature mechanical properties of AZ91 alloys are greatly improved due to grain refinement and the presence of Al2Nd and Mg12Nd. Reference | Related Articles | Metrics Cited: Baidu(2)

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Mycelial growth of fermentation medium of white Hypsizigus marmoreus and the optimization of exopolysaccharides medium FANG Lu, QI Qiu-Yue, LI Bin, JIA Ze-Feng J4    2012, 25 (1): 24-31.   DOI: 10.3976/j.issn.1002-4026.2012.01.006 Abstract （1958）      PDF（pc） （1479KB）（1975）       Knowledge map    The optimum liquid medium of white  Hypsizigus marmoreus can provide the fundamental data for its extensive cultivation. We optimized fermentation medium with L9(34) orthogonal test, the main ingredients of glucose, yeast powder, KH2PO4 and MgSO4, and exopolysaccharides content and mycelial biomass as test indexes. We also separated mycelia by extraction and filtering, dried and weighted them, and calculated their biomass. Phenol sulfuric acid was then employed to determine the content of exopolysaccharides. Weighted evaluation of exopolysaccharides content and mycelial biomass shows that the optimum liquid medium is composed of glucose of 3%, yeast powder of 0.15%, KH2PO4 of 0.30% and MgSO4 of 0.20%. Related Articles | Metrics Cited: Baidu(6)

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Mechanism of Huangqi Liujunzi decoction in treating the recovery stage of COVID-19 based on network pharmacology WANG Zong-qing, NIE Hong-ke, LI Qing-xuan, WANG Xing-qiang, TANG Xiao-hu Shandong Science    2020, 33 (5): 14-26.   DOI: 10.3976/j.issn.1002-4026.2020.05.002 Abstract （1958）      PDF（pc） （10098KB）（5226）       Knowledge map    We aimed to investigate the mechanism of Huangqi Liujunzi decoction in the treatment of COVID-19 based on Network Pharmacology.The chemical components and targets of Huangqi Liujunzi decoction were collected from the databases of TCMSP, Pubchem, and Swiss Target Prediction and standardized using the Uniprot database.COVID-19 related genes were obtained by the GeneCards database,and we further mapped the common genes of disease and drugs.The protein-protein interaction data were downloaded from the STRING database, and the components-key targets visual network graph and protein interaction network were constructed using Cytoscape software to screen out the core targets.The GO function and KEGG pathway enrichment were analyzed by R language algorithm, and the target-pathway network was constructed using Cytoscape software.The results showed that 145 compounds and 1618 corresponding targets were screened. The key active components included luteolin,kaempferol,nobiletin,naringenin,baicalein, and acacetin.The key targets included MAPK1/3/8/14,CASP3/8,IL6/1β,ALB,apoptosis regulatory protein,PTGS2,protooncogene, and protooncogene of REL.GO function enrichment analysis included 1421 biological processes, 63 molecular functions, and 36 cell components;KEGG pathway enrichment analysis revealed 41 pathways, including PI3K-Akt signaling pathway, apoptosis, endocrine resistance,MAPK signaling pathway,Toll-like receptor signaling pathway,and osteoclast differentiation.Huangqi Liujunzi Decoction has a therapeutic effect on COVID-19 through antiviral, anti-inflammatory, and immune regulation mechanisms.  Reference | Related Articles | Metrics

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esearch on heterogeneous model based key cloud computing technologies ZHANG Qing-Ke, YANG Bo, WANG Lin, CHEN Zhen-Xiang J4    2011, 24 (5): 56-62.   Abstract （1948）      PDF（pc） （1836KB）（2560）       Knowledge map            This paper presents a CPU-GPU heterogeneous parallel programming model based on the distributed programming technology of cloud computing, Map/Reduce. This paper also gives its principle and implementation process. It improves the efficiency of large-scale data processing with the multi-thread parallel mechanism, CUDA. We contrastively analyze two typical distributed storage systems, GFS and HDFS. We eventually present the threelayer architecture and basic type of virtualization technology. Reference | Related Articles | Metrics

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Impact of tube PECVD process on the refracitve index of silicon nitride thin film REN Xian-Kun, MA Yu-Ying, ZHANG Li-Ming, LIU Peng, JIANG Yan-Sen, XU Zhen-Hua, JIA He-Shun, CHENG Liang, ZHANG Chun-Yan J4    2012, 25 (3): 58-61.   DOI: 10.3976/j.issn.1002-4026.2012.03.012 Abstract （1945）      PDF（pc） （1237KB）（4404）       Knowledge map          Refraction index is an important parameter reflecting film composition and density. It also reflects preparation quality of thin film, which directly affects the transformation efficiency of a solar cell. This paper investigated the impact of radio frequency power, chamber pressure, substrate temperature and the ratio of saline and ammonia on the refraction index of silicon nitride thin film deposited on a c-Si solar cell. We analyze the reason that refractive index of azotized silicon thin film changes with different deposition conditions. Related Articles | Metrics

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A DNS based reducing sugar detector GAO Gao-Heng, ZHOU Wan-Li, ZHU Si-Rong, BI Chun-Yuan, DIAO Xiao-Hua, SHI Jian-Guo J4    2012, 25 (3): 95-97.   DOI: 10.3976/j.issn.1002-4026.2012.03.020 Abstract （1944）      PDF（pc） （1137KB）（1953）       Knowledge map           We designed a DNS based reducing sugar detector. It has such advantages as low-concentration reducing sugar detection, convenient operation, easy maintenance, high accuracy and good repeatability. It employs colorimetry to detect the differential light absorption value of dye liquor before and after heating and then to calculate the content of reducing sugar in a sample. We discover that the content of reducing sugar is proportional to the light absorption value. Glucose of 0.1% is used to calibrate measurement. The linear rate of more than 0.99 exists when the concentration range is between 0% and 0.1%. The detector can stably detect the content of reducing sugar in beer, sorbitol and ferment. Related Articles | Metrics

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A raw material decoloring technology in the production of medical anhydrous glucose WANG Hui, LIU Jian-Xia, CHENG Ping, GUO Yu-Bo, GENG Pei-Jiang, XU Xiao-Fei J4    2011, 24 (4): 50-51.   Abstract （1943）      PDF（pc） （1072KB）（1698）       Knowledge map            We investigated the influences of glucose solution concentration, diatomite model, volume of mixed decolorants, ratio of activated charcoal and diatomite on decoloring efficiency with the running time in the deckleboard of mixture of glucose raw materials and decolorants as a parameter to increase decoloring efficiency and to decrease the costs in the production of medical anhydrous glucose. Orthogonal experiment shows that the parameter can reach the maximum in the conditions of 69% glucose liquid concentration, 700# diatomite, 7‰ volume of decolorants and 5:2 ratio of activated charcoal and diatomite. Moreover, the employment of mixed decolorants decreases the amount of activated charcoal and filter cloth by almost 30%, so production costs are reduced. Related Articles | Metrics

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Research advances in chemical constituents of Gastrodia elata Blume LI Yun, WANG Zhi-wei, LIU Da-hui, WANG Xiao, ZHOU Hong-lei SHANDONG SCIENCE    2016, 29 (4): 24-29.   DOI: 10.3976/j.issn.1002-4026.2016.04.006 Abstract （1935）      PDF（pc） （1064KB）（2352）       Knowledge map    Gastrodia elata Blume is a valued Chinese herbal medicine that has a long medical history. From 50’s in the last century, researchers have isolated multiple chemical constituents from it, including phenols, organic acids, polysaccharides, steroids, etc. Among the isolated nearly one hundred compounds, phenols and polysaccharides are highlighted, while other trace elements are less involved.Further investigating the relevance between the contents of its active constituents and symbiotic bacteria can guarantee its quality and yield. We review the chemical composition isolated by global researchers and make a prospect and discussion. This provides reference for its better development and utilization. Reference | Related Articles | Metrics Cited: Baidu(3)

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Rapid determination of the composition of corn steep water FENG Wen-Hong, MENG Qing-Jun, ZHANG Li-Qun, YANG Yan, SHI Jian-Guo J4    2011, 24 (4): 45-49.   Abstract （1928）      PDF（pc） （1009KB）（1928）       Knowledge map            This paper presents a rapid detection method for the composition of corn steep water and provides the basis for optimal control of steeping process.We employ biosensors and an automatic analyzer to determine the contents of reducing sugar, glucose and lactic acid in corn steep water and present their variation rule. Detection results show that the content of reducing sugar, glucose and protein initially decreases and then increases, but the content of lactic acid initially increases and then decreases. Moreover, this biosensor detection method has less error and offers simpler operation, so rapid detection goal can be achieved. Reference | Related Articles | Metrics Cited: Baidu(3)

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Effects of ZnO content on the crystallization and property of Li2O-ZnO-SiO2 glass CHEN Li-Zong, WU Shou-Ping, TIAN Qing-Bo J4    2011, 24 (5): 26-29.   Abstract （1919）      PDF（pc） （1542KB）（1790）       Knowledge map         We addressed the effects of different ZnO content on the crystallization behavior and property of the Li2O-ZnO-SiO2 glass system with differential scanning calorimeters (DSC), x-ray diffraction (XRD) and scanning electronic microscope (SEM). Experimental results show that its precipitated phases are cristobalite, tridymite, Li2SiZnO4and SiO2. The relative cristobalite content initially increases and then decreases with the increase of ZnO content. The cristobalite phase influenced thermal expansion coefficient α also initially increases and then decreases. The relative cristobalite content reaches the highest value when the ZnO content arrives at 21.1%.Its thermal expansion coefficient α reaches the maximum value of 19.13×10-6/℃ when the ZnO content arrives at 26.7%.   Reference | Related Articles | Metrics