靶向细胞凋亡的海洋抗肿瘤多肽药物研究进展

doi:10.3976/j.issn.1002-4026.2015.03.004

Abstract

Abstract: Apoptosis plays an important role in formation and development of a cancer. Targeting apoptotic pathway has become a significant strategy for developing chemotherapeutic agents. Marine peptides is an important source for antitumor drugs, most of which can exert antitumor effect by inducing apoptotic pathway. We survey recently discovered marine peptides and apoptotic signal pathway for drug antigenicity and drug sources in the development for such marine drugs.

Key words: apoptosis, marine peptide, antitumor

CLC Number:

LIN Xiukun,SU Shuonan. Research advances of marine antitumor peptides targeting apoptosis[J].SHANDONG SCIENCE, 2015, 28(3): 16-22.

References

［1］REED J C. Mechanisms of apoptosis［J］. Am J Pathol, 2000, 157(5):1415-1430. ［2］ BURZ C, BERINDANNEAGOE I, BALACESCU O, et al.Apoptosis in cancer:Key molecular signaling pathways and therapy targets［J］.Acta Oncol,2009,48 (6): 811-821. ［3］ GHOBRIAL I M, WITZIG T E, ADJEI A A. Targeting apoptosis pathways in cancer therapy［J］. CA Cancer J Clin，2005,55 (3):178-194. ［4］ ABE K, KURAKIN A, MOHSENIMAYBODI M, et al. The complexity of TNFrelated apoptosisinducing ligand［J］. Ann N Y Acad Sci, 2000, (926): 52-63. ［5］ OZOREN N, ELDEIRY W S. Cell surface death receptor signaling in normal and cancer cells［J］. Semin Cancer Biol, 2003,13 (2):135-147. ［6］ PETER M E, KRAMMER P H.The CD95(APO1/Fas) DISC and beyond［J］.Cell Death Differ, 2003,10 (1):26-35. ［7］ THORBURN A. Death receptorinduced cell killing［J］.Cell Signal,2004,16 (2):139-144. ［8］KROEMER G. Mitochondrial control of apoptosis: an introduction［J］. Biochem Biophys Res Commun, 2003,304 (3):433-435. ［9］ GUPTA S, KASS G E, SZEGEZDI E, et al. The mitochondrial death pathway:A promising therapeutic target in diseases［J］. J Cell Mol Med, 2009,13 (6): 1004-1033. ［10］ LIN X K, LIU M, HU C X, et al. Targeting cellular proapoptotic molecules for developing anticancer agents from marine sources［J］.Curr Drug Targets, 2010,11 (6):708-715. ［11］ZHENG L H, WANG Y J, SHENG J, et al. Antitumor peptides from marine organisms［J］.Mar Drugs, 2011,9 (10):1840-1859. ［12］ YIP KW, REED J C. Bcl2 family proteins and cancer［J］.Oncogene， 2008，27 (50) ： 6398-6406. ［13］ OKUN I, BALAKIN K V, TKACHENKO S E, et al. Caspase activity modulators as anticancer agents［J］.Anticancer Agents Med Chem,2008,8 (3): 322-341. ［14］MARTELLI A M, TAZZARI P L, EVANGELISTI C, et al.Targeting the phosphatidylinositol 3kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside［J］. Curr Med Chem， 2007,14 (19):2009-2023. ［15］ KANG M H, REYNOLDS C P.Bcl2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy［J］.Clin Cancer Res， 2009,15 (4): 1126-1132. ［16］ WONG W W, PUTHALAKATH H. Bcl2 family proteins: the sentinels of the mitochondrial apoptosis pathway［J］.IUBMB Life,2008,60 (6):390-397. ［17］ BRAEKMAN J C, DALOZE D, MOUSSIAUX B, et al.Jaspamide from the marine sponge Jaspis johnstoni［J］.J Nat Prod, 1987,50 (5):994-995. ［18］ WATTS K R, MORINAKA B I, AMAGATA T, et al. Biostructural features of additional jasplakinolide (jaspamide) analogues［J］. J Nat Prod, 2011,74 (3): 341-351. ［19］ BAI R, PETTIT G R, HAMEL E. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain［J］.Biochem Pharmacol, 1990,39 (12):1941-1949. ［20］ MAKI A, DIWAKARAN H, REDMAN B, et al. The Bcl2 and p53 oncoproteins can be modulated by bryostatin 1 and dolastatins in human diffuse large cell lymphoma［J］.Anticancer Drugs,1995,6 (3):392-397. ［21］ van de DONK N W C J, DHIMOLEA E. Brentuximab vedotin［J］. MAbs,2012,4 (4):458-465. ［22］ MINICH S S. Brentuximab vedotin:A new age in the treatment of Hodgkin lymphoma and anaplastic large cell lymphoma［J］. Ann Pharmacother, 2012,46 (3):377-383. ［23］ HUANG T C, LEE J F, CHEN J Y. Pardaxin, an antimicrobial peptide, triggers caspasedependent and ROSmediated apoptosis in HT1080 cells［J］. Mar Drugs, 2011,9(10):1995-2009. ［24］ NOGLE L M, GERWICK W H. Somocystinamide A, a novel cytotoxic disulfide dimer from a Fijian marine cyanobacterial mixed assemblage［J］.Org Lett,2002,4 (7):1095-1098. ［25］ WRASIDLO W, MIELGO A, TORRES V A, et al. The marine lipopeptide somocystinamide A triggers apoptosisviacaspase 8［J］.Proc Natl Acad Sci U SA， 2008,105 (7):2313-2318. ［26］ SCHIRMER T, HUBER R, SCHNEIDER M, et al. Crystal structure analysis and refinement at 2.5 A of hexameric Cphycocyanin from the cyanobacterium Agmenellum quadruplicatum.The molecular model and its implications for lightharvesting［J］.J Mol Biol,1986,188 (4):651-676. ［27］ LI B, GAO M H, ZHANG X C, et al. Molecular immune mechanism of Cphycocyanin from Spirulina platensisinduces apoptosis in HeLa cells in vitro［J］.Biotechnol Appl Biochem,2006,43 (3):155-164. ［28］ SCORRANO L. Opening the doors to cytochrome C: Changes in mitochondrial shape and apoptosis［J］. Int J Biochem Cell Biol, 2009,41 (10):1875-1883. ［29］ CHENG L Y, WANG C G, LIU H Z, et al.A novel polypeptide extracted fromCiona savignyi induces apoptosis through a mitochondrialmediated pathway in human colorectal carcinoma cells［J］. Clin Colorectal Cancer, 2012,11 (3): 207-214. ［30］ WANG C C, LIU M, CHENG L Y, et al. A novel polypeptide from Meretrix meretrix Linnaeus inhibits the growth of human lung adenocarcinoma［J］. Exp Biol Med, 2012,237 (4):442-450. ［31］ DHANASEKARAN D N, REDDY E P. JNK signaling in apoptosis［J］. Oncogene, 2008,27 (48):6245-6251. ［32］ DEPENBROCK H, PETER R, FAIRCLOTH G T, et al.In vitro activity of aplidine, a new marinederived anticancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells［J］.Br J Cancer, 1998,78 (6):739-744. ［33］ URDIALES J L, MORATA P, NUNEZ de CASTRO I, et al.Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates［J］.Cancer Lett, 1996,102 (1/2):31-37. ［34］ RINEHART K L. Antitumor compounds from tunicates［J］. Med Res Rev, 2000, 20 (1):1-27. ［35］ FAIVRE S, CHIZE S, DELBALDO C, et al. Phase I and pharmacokinetic study of aplidine, a new marine cyclodepsipeptide in patients with advanced malignancies［J］.J Clin Oncol, 2005,23 (31):7871-7880. ［36］ MAROUN J A, BELANGER K, SEYMOUR L, et al.Phase I study of Aplidine in a daily × 5 onehour infusion every 3 weeks in patients with solid tumors refractory to standard therapy. A National Cancer Institute of Canada Clinical Trials Group study: NCIC CTG IND 115［J］.Ann Oncol, 2006,17 (9):1371-1378. ［37］ NALDAMOLINA R, VALENZUELA B, RAMONLOPEZ A, et al. Population pharmacokinetics metaanalysis of plitidepsin (Aplidin) in cancer subjects［J］.Cancer Chemother Pharmacol, 2009,64(1):97-108. ［38］BRUGGE J, HUNG M C, MILLS G B. A new mutational Aktivation in the PI3K pathway［J］. Cancer Cell , 2007,12 (2):104-107. ［39］ YU L, WANG L T, CHEN S W. Dual character of Tolllike receptor signaling: Protumorigenic effects and antitumor functions［J］. Biochim Biophys Acta, 2013, 1835 (2):144-154. ［40］ HAMANN M T, OTTO C S, SCHEUER P J, et al. Kahalalides: Bioactive peptides from a marine mollusk Elysia rufescens and its algal diet Bryopsis sp.(1)［J］. J Org Chem, 1996,61 (19): 6594-6600. ［41］ JANMAAT M L, RODRIGUEZ J A, JIMENO J, et al.Kahalalide F induces necrosislike cell death that involves depletion of ErbB3 and inhibition of Akt signaling［J］. Mol Pharmacol, 2005,68 (2):502-510. ［42］ LING Y H, ARACIL M, ZOU Y, et al.PM02734 (elisidepsin) induces caspaseindependent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of deathassociated protein kinase［J］.Clin Cancer Res, 2011, 17 (16):5353-5366. ［43］ LING Y H, ARACIL M, JIMENO J, et al.Molecular pharmacodynamics of PM02734 (elisidepsin) as single agent and in combination with erlotinib;synergistic activity in human nonsmall cell lung cancer cell lines and xenograft models［J］.Eur J Cancer, 2009,45 (10):1855-1864. ［44］ TEIXIDO C, ARGUELAGUET E, PONS B, et al.ErbB3 expression predicts sensitivity to elisidepsin treatment:in vitro synergism with cisplatin, paclitaxel and gemcitabine in lung,breast and colon cancer cell lines［J］. Int J Oncol, 2012,41 (1): 317-324. ［45］ GARCIAFERNANDEZ L F, LOSADA A, V ALCAIDE, et al.Aplidin induces the mitochondrial apoptotic pathwayviaoxidative stressmediated JNK and p38 activation and protein kinase C delta［J］. Oncogene, 2002,21 (49):7533-7544. ［46］ CIOCA D P, KITANO K. Induction of apoptosis and CD10/neutral endopeptidase expression by jaspamide in HL60 line cells［J］. Cell Mol Life Sci， 2002,59 (8):1377-1387. ［47］ SATO M, SAGAWA M, NAKAZATO T, et al.A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells［J］. Int J Oncol,2007,30 (6):1453-1459. ［48］ RINEHART K L,GLOER J B,HUGHES R G, et al. Didemnins: Antiviral and antitumor depsipeptides from a Caribbean tunicate［J］. Science, 1981,212 (4497):933-935. ［49］ CHUN H G, DAVIES B, HOTH D, et al. Didemnin B［J］. Invest New Drug, 1986,4 (3):279-284. ［50］ RINEHART K L, HOLT T G, FREGEAU N L, et al. Bioactive compounds from aquatic and terrestrial sources［J］. J Nat Prod, 1990,53 (4):771-792. ［51］ PAN P S, VASKO R C, LAPERA S A, et al.A comprehensive study of Sansalvamide A derivatives: the structure–activity relationships of 78 derivatives in two pancreatic cancer cell lines［J］ Bioorg Med Chem, 2009,17 (16):5806-5825. ［52］ HWANG Y, ROWLEY D, RHODES D, et al. Mechanism of inhibition of a poxvirus topoisomerase by the marine natural product sansalvamide A［J］.Mol Pharmacol, 1999,55 (6):1049-1053. ［53］HAMBLEY T W, HAWKINS C J, MF LAVIN, et al. Cycloxazoline:A cytotoxic cyclic hexapeptide from the ascidianLissoclinum bistratum［J］. Tetrahedron, 1992,48:341-348. ［54］WATTERS D J, BEAMISH H J, MARSHALL K A, et al.Accumulation of HL60 leukemia cells in G2/M and inhibition of cytokinesis caused by two marine compounds, bistratene A and cycloxazoline［J］.Cancer Chemother Pharmacol, 1994,33 (5):399-409. ［55］CARROLL A R, FENG Y, BOWDEN B F, et al. Studies of Australian ascidians. 5.Virenamides A–C, new cytotoxic linear peptides from the colonial didemnid ascidian Diplosoma virens［J］.J Org Chem, 1996,61 (12):4059-4061.

[1]	ZHANG Nannan, ZHOU Yifan, ZHU Yi, AN Mingyu, DENG Ying, LI Jun. Identification and compound screening of copper-induced cell death-related genes SLC31A1 and DBT in hepatocellular carcinoma [J]. Shandong Science, 2024, 37(1): 39-50.
[2]	SHI Ruidie, GAO Xin, WANG Baokun, GAO Daili, JIN Meng, ZHANG Xiujun. Anti-Alzheimer's disease activity of oroxin A and its mechanism of action based on zebrafish model [J]. Shandong Science, 2023, 36(6): 28-37.
[3]	SONG Zeyu, LI Zhenyuan, PAN Tao, MENG Xiangting, LI Song, DONG Hailun, FAN Huaying. Protective effect and mechanism of quercetin on adriamycin-induced nephrotic syndrome in rats [J]. Shandong Science, 2023, 36(4): 61-68.
[4]	MO Cai-lian, LI Jie, WANG Jia-zhen, LIU Xin , LIN Sheng-hua, MOU Yan-ling, ZHANG Yun, LIU Ke-chun, HE Qiu-xia. Applicability of a zebrafish thrombosis model in screening active ingredients of traditional Chinese medicine [J]. Shandong Science, 2021, 34(4): 52-59.
[5]	MEI Ming, ZHOU Jin, HUANG Wen-tao, MA Liang-peng, YANG Ming, HU Song. Anti-benign prostatic hyperplasia activity of ethanol extract obtained from Catharsisus molossus Linnaeus [J]. Shandong Science, 2020, 33(5): 51-56.
[6]	MU Yan, LI Li-li, MA Shuang-shuang, SONG Yue, Wang Quan-bo. Metabolomics mechanism of Pb²⁺induced cytotoxicity to microglial cells [J]. Shandong Science, 2019, 32(6): 26-33.
[7]	LIU Fa-sheng, WANG Rong-chun, GUO Jing-lan, CHEN Yan-li, XIA Qing, KONG Hao-tian, FENG Run-liang, HAN Li-wen, ZHANG Ai-ping, LIU Ke-chun. The immune-regulatory effects of active ingredients of asparagus using zebrafish model [J]. SHANDONG SCIENCE, 2017, 30(6): 29-34.
[8]	PENG Wei-bing, ZHOU Ling-xiao, FU Xian-jun, HE Qiu-xia, WANG Zhen-guo, LIU Ke-chun. Anti-inflammatory research on component combination of Kunhai ginger decoction based on zebrafish model [J]. SHANDONG SCIENCE, 2017, 30(2): 37-42.
[9]	SUN Chen, HE Qiu-xia, HAN Li-wen, CHEN Xi-qiang, WANG Xi-min, CHU Jie, HAN Jian, WANG Rong-chun, HOU Hai-rong, LIU Ke-chun. Toxicity of aspirin to gastrointestinal tract of zebrafish [J]. SHANDONG SCIENCE, 2016, 29(6): 50-55.
[10]	HOU Hai-rong,ZHANG Shan-shan,SUN Chen, CHEN Yu-feng, HE Qiu-xia,LI Xiao-bin, YU Tao, PENG De-jie, HAN Li-wen, LIU Ke-chun. The effect of fructo oligosaccharides and isomaltooligosaccharide on the intestinal peristalsis of zebrafish [J]. SHANDONG SCIENCE, 2016, 29(6): 56-61.
[11]	ZOU Yu,ZHANG Yun,HAN Liwen,HE Qiuxia，LI Zhiping，HOU Hairong，HAN Jian，WANG Ximin，LI Juanjuan，CEN Juan，LIU Kechun. Impact of isoniazid on developmental toxicity and behavior of zebrafish larvae [J]. SHANDONG SCIENCE, 2016, 29(5): 47-53.
[12]	HAN Jian, PENG Weibing, HAN Liwen, HE Qiuxia, ZHANG Yun, SUN Chen, WANG Rongchun, CHU Jie, LIU Kechun. Impact of Cu,Hg and Pb on liver growth of zebrafish larvae [J]. SHANDONG SCIENCE, 2016, 29(5): 54-59.
[13]	DONG Qi,GAO Zhihui. Experiments of antitumor effect of Cordyceps militaris capsules on S180 mouselet [J]. SHANDONG SCIENCE, 2016, 29(2): 25-29.
[14]	WANG Rongchun，HAN Liwen，CHEN Xiqiang，HE Qiuxia，WANG Ximin，PENG Weibing，SUN Chen，HAN Jian，LIU Kechun. Inhibitory effect of aloe emodine on cervical cancer cell line SiHa with zebrafish xenograft model [J]. SHANDONG SCIENCE, 2016, 29(2): 14-18.
[15]	ZHANG Shanshan, HE Qiuxia, HAN Jian, WANG Xue, HOU Hairong, LI Xiaobin,ZHANG Xuanming, HAN Liwen, LIU Kechun. Evaluation of bone mineralization promotion of glucosamine hydrochloride and epimedium extract with zebrafish model [J]. SHANDONG SCIENCE, 2016, 29(2): 19-24.

Research advances of marine antitumor peptides targeting apoptosis

PDF (PC)

Like

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 0