Abstract: We addressed the impact of aloeemodine on embryos growth and behavior of zebrafish with zebrafish embryo as a model. Experimental results show that aloeemodineof more than 1.0 μg/mL concentration has lethal effect to zebrafish embryos. This effect is strengthened with the increase of concentration and action time. Aloeemodine has obstruction effect to the incubation of zebrafish embryos. Aloeemodine of more than 1.0 μg/mL concentration makes zebrafish embryos to exhibit such malformation as yolk abnormal extension, growth retardation and body bending. However, Aloeemodine has no obvious effect on the behavior of zebrafish larvae. Experimental results demonstrate that we should fully consider aloeemodine dosage and medication time when we clinically apply aloeemodine to the treatment for such special patients as pregnant women.

Key words: developmental toxicity, behavior, aloeemodine, zebrafish