In this study, a monitoring alarm and technical remote support system, featuring a monitoring alarm, maintenance and fault diagnosis material sharing, operational work software sharing, and online support, has been designed and developed based on the B/S structure and Java server pages (JSP) as a development tool with respect to the mesoscale automatic weather stations. The developed system provides technical and software support for realtime and effective fault monitoring, maintenance, and fault diagnosis at automatic weather stations. The operation results denote that the proposed design improves the time efficiency and accuracy of the equipment support with respect to the automatic weather stations as well as the professional competence of its personnel.

To study the optimal preparation process of chicoric acid liposome, thin-film dispersion ultrasound was used, and the encapsulation efficiency was evaluated to examine the preparation effects. The Box-Behnken design response surface methodology was adopted to optimize the preparation parameters. The results showed that the optimal ratio of phospholipid to cholesterol was 4.20:1, the mass ratio of phospholipid to pharmaceutical was 11.44:1, and the ultrasound time was 6.54 min. The encapsulation efficiency of liposome prepared by the optimal process was 75.18%. The use of Box-Behnken design response surface methodology led to an optimal preparation process, and the obtained process is reasonable and feasible.

High performance liquid chromatography (HPLC) was used to establish the characteristic fingerprint of Semiaquilegiae Radix and to determine the content of lithospermoside and griffonilide. The chromatographic conditions were as follows: TSKgel ODS-100V (250 mm×4.6 mm, 5 μm), acetonitrile-0.2% phosphoric acid solution as mobile phase, flow rate of 0.4 mL·min^-1, and detection wavelength of 258 nm. Cluster analysis was performed to compare the drugs of Semiaquilegiae Radix of different origins and batches. Eight common peaks were determined and two chromatographic peaks were identified with the use of the similarity evaluation system of traditional Chinese medicine fingerprint. The similarity among 15 batches of medicinal materials was more than 0.90. The method is simple and stable, producing authentic and reliable data. It can be used as the research evidence of quality identification, quality control, and resource development and utilization in Semiaquilegiae Radix.

The contents of paeonol and paeoniflorin in the leaves of Paeonia suffruticosa from six growing areas were determined using high-performance liquid chromatography (HPLC). Both chemicals were analyzed using Waters Xbridge shield RP18 chromatography columns (5 μm, 4.6 mm×150.0 mm) at 30℃ with a flow rate of 1.0 mL/min. The sample loading amount was 10 μL. For paeonol analysis, the mobile phase was methanol-water (45:55，V/V) solution with the detection wavelength set at 275 nm. For paeoniflorin analysis, acetonitrile-0.1% phosphoric acid (12:88，V/V) solution was used as the mobile phase with a detection wavelength of 230 nm. Paeonol and paeoniflorin showed good linear relationship with peak area within the concentration ranges of approximately 12.5~400.0 μg/mL and 50.0~800.0 μg/mL, respectively. The results demonstrated satisfying precision, stability, repeatability and sample recovery. The leaf contents of paeonol and paeoniflorin in Paeonia suffruticosa vary among the six growing areas. Chemical composition analysis of Paeonia suffruticosa leaves, in cases of paeonol and paeoniflorin, provides accurate and rapid quantitative analytical methods for qualitative evaluation and scientific explanation of the pharmaceutical effects. Moreover, it also provides data support for investigating the diverse chemical composition of Paeonia suffruticosa leaves from different areas, thus facilitating their exploitation and utilization.

In this study, soy whey water discharged during the process of soybean protein isolate production by using alkali solution and acid isolation served as raw material. Following separation by sedimentation, layered separation by sodium carbonate addition and extraction with ethyl acetate, rotary evaporation was performed, and adsorption and elution was then conducted with the use of macroporous resin. Daidzein was finally obtained. Daidzein was subjected to purification.The purification effects of five types of macroporous resins were compared, and it was found that ADS-21 produced the best effect. The purity of daidzein sample was 98.5%, as detected by thin-layer chromatography scan (TLCS). Thus, it can be used in medicines, healthcare products, and standard substance for test use. The method proposed in this study can be used for large-scale production of daidzein.

To investigate the effects of Rhizome Drynariae on bone microarchitecture of ovariectomized rats and to explore its possible mechanisms. Thirty-six rats were divided into experimental group (OVXDF), model group (OVX), and sham operation group (SHAM). In the OVXDF and OVX groups, bilateral ovaries were removed. Eight weeks after operation, bone mineral density was measured. After this, the OVXDF group was administered Rhizoma Drynariae intragastrically, and the OVX and SHAM groups received normal saline intragastrically for 12 weeks. Subsequently, micro-CT was used to measure bone mineral density (g/cm³), bone mineral content (g), trabecular bone volume over total volume (%), and trabecular thickness Tb.Th(μm), trabecular bone number Tb.N(mm^-1), trabecular bone separation degree Tb.sp (mm), and structural model index. Rat microscopic morphology of the bone tissue was observed under microscope. Concentrations of tartrateresistant acid phosphatase, matrix metallopeptidase 9, and CTX-1 in rat serum were measured by enzyme-linked immunosorbent assay. The experiment results showed not only decreased bone mass but also changed bone microarchitecture in ovariectomized rats. Rhizoma Drynariae decocted with water intragastrically can effectively compensate for the decrease in bone mineral density and the change in bone microarchitecture in ovariectomized rats. Its mechanism of action is associated with its inhibition of bone marrow adipocyte formation and suppression of activity and number of osteoclasts.

Respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in infants. Toll-like receptors, one of the pattern recognition receptors involved in innate immunity, play an important role in the identification and eradication of RSVs. However, this is not adequately examined, which has limited the development of antiviral drugs and vaccines. In this study, we reviewed the studies on the immunologic process of RSV-related Toll-like receptors in recent years and described the shortcomings of the methods and tendencies of the current studies. This is intended to provide ideas and methods for the further studies on new anti-RSV drugs and their mechanisms.

The potential active components of Wulingsan were obtained using the TCMSP database, and the potential targets were predicated using PharmMapper servers. The compoundtarget and protein-protein interaction (PPI) networks were constructed to perform enrichment analyses of gene ontology (GO) and biological pathway based on the Kyoto Encyclopedia of Genes and Genomes (KEGG). Results show that a compound-target network comprising 50 major active components and 459 targets was obtained; the key targets included CSDE1, PRPS1, HSD17B4, CLPP, ACBD7, and AZGP1. A PPI network responsible for constructing Wulingsan targets consisted of 155 nodes and 527 interactions; key targets included CSDE1, CITED2, RANBP2, HSD17B4, TAF13, and SOD2. The items associated with the GO enrichment analysis pathway primarily involved cytosol, protein, and small molecules as well as cells’ reaction to organic substances and chemical stimulations, nitrogen metabolism, organic matter metabolism, and ion binding and transport activity. A KEGG metabolic pathway enrichment analysis included proteoglycans in cancer as well as bladder cancer, prostate cancer, endocrine resistance, fluid shear stress, and atherosclerosis. Results initially verified molecular mechanism for the pharmacological action of the main active components of Wulingsan, thereby providing evidence for further elucidation of its molecular mechanism, predicting its potential targets (such as PRPS1 and HSD17B4), and delivering a new method for studies on Wulingsan development and application.

The hot filament chemical vapor deposition method was employed to optimize the preparation process of diamond films. Multilayer diamond films with uniform thickness were successfully prepared by altering their methane concentration, making it possible to prepare diamond films in various modulation cycles. The modulation cycle was as low as 100 nm .A stress analysis of single and multilayer diamond films was conducted using Raman spectroscopy and X-ray diffraction methods. It was found that the stress onmicrodiamond films in the single-layer structure was the highest, and would decrease as the size of diamond grains increased. In the multilayer structure of diamond films, the microlayer and nanolayers alternately grow in a uniform manner, which effectively reduces the stress on the films and improves their stability in applications.

There is a great demand for online monitoring of various characteristic gases in the precision fermentation process. In this paper, based on the tunable diode laser absorption spectroscopy (TDLAS) technology, the carbon dioxide monitoring and analysis system was developed for the detection of gases in the precision fermentation process. The measurement range of 0~2% and the response time of 5.46 s were realized. In addition, the measurement error can be lower than 0.08% within the full measurement range. The results of field test demonstrated the advantages of high sensitivity, excellent stability, and reliability of the developed CO₂ monitoring system. The CO2 monitoring system based on the TDLAS technology is extremely suitable for insitu characteristic gas monitoring and has great application potential in the precision fermentation process. 

With respect to the demand for civil aviation passenger transport in the development of international tourism in border areas with concentrations of ethnic minorities, this essay constructs the VAR model between inbound tourism and civil aviation passenger transport taking Yunnan province as an example. Moreover, it analyzes the long-term equilibrium relationship between the two factors using the Johansen cointegration test and Granger causality test analysis, and investigates the dynamic correlations between civil aviation passenger transport and international tourism in border areas with concentrations of ethnic minorities using the impulse response function and variance decomposition. Results show that there is a co-integration relationship, a two-way Granger causal relationship (the two factors complementing and promoting each other) and a long-term stable equilibrium relationship between international tourism and civil aviation passenger transport of Yunnan. At the same time, it was found that the cumulative impulse response of international tourism income and number of tourists to civil aviation indicators is positive, and the contribution rate of civil aviation passenger transport to international tourism development is basically more than 50%, indicating that civil aviation passenger transport plays an important and continuous role in promoting international tourism of border areas with concentrations of ethnic minorities.

Eight typical ports in Shandong (e.g. Yantai, Qingdao, Weifang, Dongying, Rizhao) are studied in this paper. By fully considering the particularity of the development of Shandong Peninsula, Bohai Bay and the southern areas；in light of grand environment of port resource in Shandong Province; and the status quo of port development, thereof, this paper analyses the differences between regional ports and the necessity of forming port alliance. On this basis, the relevant panel data of Shandong regional ports from 2011 to 2017 are analyzed using vector auto-regression, the interaction between ports and economic development are analyzed, the influence of specific factors on regional port development through fixed effect regression model are further analyzed. The study finds that there is an interactive effect between regional ports and economic development, and the ports-to-economic contribution is stronger than economy-to-port contribution. Specifically, the regional economic level, industrial structure and infrastructure, and other heterogeneous economic factors have significant impacts on the development of Shandong regional ports.

The installation of hydraulic regenerative braking system will change the original antilock braking system of a semitrailer train combination while improving its energy efficiency. To ensure the safety of the braking system, it is necessary to integrate the regenerative braking system with the original antilock braking system. Based on the braking system that distributes the three-axle braking force in the fixed proportion, a coordinated control strategy of optimal braking energy recovery and antilock braking is proposed herein. Considering the braking force strength, energy storage state, and road adhesion conditions, the mechanical friction and regenerative braking force are distributed among three axles. Simultaneously, the friction braking force is adjusted to control the wheel slip rate. A co-simulation model of AMESim and MATLAB/Simulink is built. The specific condition is simulated on thesimulation platform. The results show that the proposed coordinated control strategy can achieve 13.48% of braking energy recovery efficiency in the middle and low adhesion roads and medium braking force conditions while the slip rate of three-axle is maintained within the optimal range. 

The energy consumption of urban rail-transit trains is mainly influenced by their line conditions and operation organization scheme. To accurately simulate the relationship between line operating conditions and train operation energy consumptions, this study presents a rail-transit train simulation model that has an energy-efficient speed profile. Each interstation section consists of three phases: maximum acceleration, coasting, and maximum braking. The proposed model considers the characteristics of the train operation between the stations and the impact of the train marshaling scheme and the design of the energy-saving slope on the energy consumption of trains. This simulation model consists of three components: train force analysis, interstation train operation strategy design, and energy consumption calculations. Different line conditions and train marshaling schemes are designed on the Visual studio platform to perform the simulation, and the effect on the energy consumption of trains and the characteristics of energy consumption are analyzed. The results show that logical energy-saving slope design and train marshaling scheme plans are beneficial to reduce the train operation energy consumption.

Herein, the simulated methylene blue dye wastewater was treated by boron-doped diamond film electrode group. Film quality and effects of initial concentration of methylene blue, solution pH, electrolyte dosage, and applied current density on the removal of boron-doped diamond film were investigated, and reaction kinetics simulation was conducted. Results show that the removal rate constant, removal rate of methylene blue, and solution COD removal rate increased with an increase in the pH, electrolyte, and current density. When the initial pH increased from 4 to 10, the methylene blue removal rate constant increased from 0.001 4 s^-1  to 0.003 3 s^-1, whereas removal rate increased from 53.9% to 85.8%. With the electrolyte dosage increased from 1 g to 4 g, the removal rate constant increased from 0.001 7 s^-1 to 0.005 1 s^-1, whereas the removal rate increased from 61.0% to 94.2%. When the current density increased from 18.75 mA/cm² to 75.00 mA/cm², the removal rate constant increased from 0.000 3 s^-1 to 0.003 8 s^-1, whereas the removal rate increased from 18.1% to 92%. The effect of the initial concentration of methylene blue was small. When the addition of electrolyte is insufficient or the current density was significantly large, the temperature of the solution increased considerably, and the excess electric energy is converted into the thermal energy of the solution.

Most studies of convection-diffusion equation are in the range of constant coefficient or integer order. To more accurately describe the solute movement features, the traditional integer order convection-diffusion equation is extended to cases of fractional order variable coefficient. The paper primarily investigated the finite difference decomposition method of Caputo fractional order convection-diffusion equation with variable coefficients. This paper introduced a half integer point, performed dual partitioning on the spatial grid,and then discretized the spatial derivatives using the finite difference method. Theoretical analysis shows that the solution of the discrete format proposed in this paper exists and is unique, with a convergence accuracy of ο(τ+h).The accuracy of theoretical analysis is verified using one-dimensional numerical examples.

Using fixed point theorem of Banach, this paper discussed the existence and uniqueness of positive solutions for integro-differential equations on the infinite interval wherein the boundary conditions are non-negative constant. Furthermore, the dependence of positive solutions on boundary values was discussed as well.

The outbreak of COVID-19 is seriously endangering human and public health. It has caused great concern all around the world. The most effective measure to prevent viral diseases is vaccination. But there has no specific vaccine been approved for this disease yet. Considering the serious effect of the epidemic,this article reviewed the related vaccines research on influenza viruses and coronaviruses, and their amino acid sequences were compared. The results show that there are some similarity between the spike of 2019-nCoV and hemagglutinin from influenza A virus and influenza B virus. The hemagglutinin of influenza is the major targets of current commercial sensonal influenza vaccines which imply that vaccines might be beneficial for prevention of COVID-19. Besides that, because of the high similarity between spike and nucleocapsid of SARS-CoV and 2019-nCoV, we believe that the SARS-CoV vaccine may be an alternative that can be used for the control of COVID-19 in the short term.

Based on the theory of principle, method and prescription of Treatise on Febrile Diseases written by Zhang Zhongjing, we analyzed the etiology and pathogenesis of COVID-19(corona virus disease 2019) that is currently prevalent. Reasonable diagnosis and treatment suggestions for prevention and control were proposed. 2019-nCoV is regard as a kind of typhoid virus, and COVID-19 should be defined as what Zhongjing called typhoid, a kind of cold-induced disorders. It is not suitable for the febrile patients infected by 2019-nCoV who are afraid of cold to cool down or diminish inflammation by intravenous fluids. The study could provide valuable guidance for the prevention and control for not only the COVID-19, but also the similar epidemic infectious diseases in the future.

The outbreak of COVID-19 has resulted in the realization of important requirements with respect to the traffic emergency prevention and control system of China. This study discusses the COVID-19 patient transfer problem through intelligent transportation and then proposes algorithms and models for transferring patients to achieve a highly efficient transition between patients and medical resources. A comprehensive application system involving a three-dimensional transportation is established to optimize the match between traffic resources and medical resources, which will maximize the transportation use to connect resources. In addition, this study proposes a joint prevention and control system, discussing the functions of the Internet of Things, the communication technology and traffic control methods during the prevention and control of COVID-19 and patients treatment. Finally, we conclude the functions of traffic planning during the prevention and control of the outbreak of COVID-19 and propose the establishment of a rapid response system for key public health and safety events. The comprehensive application of intelligent transportation technology in this study can be adopted to improve the response and disposal capacity in events of public health and security emergencies. 

To evaluate the control potential of Trichoderma wettable powder against tomato Fusarium wilt, we tested the control efficacy of Trichoderma wettable powder (2×10⁸  cfu/g) on tomato Fusarium wilt in field experiments. The result demonstrated that the use of Trichoderma wettable powder (15 000 g/hm²) could remarkably control Fusarium wilt diseases for tomatoes and the efficacy was maintained at >70% after 90 days of treatment. Therefore, the control efficacy of Trichoderma wettable powder on tomato Fusarium wilt was equivalent to that of the control agent. This was suitable to control tomato Fusarium wilt and could significantly promote the growth of tomatoes.

The teeth of a powder metallurgy gear were fractured during operation. A large number of globular iron-carbon compounds were found at the fracture site using SEM and EDS analysis, which indicates a weak bonding between powders resulting from an insufficient sintering temperature and duration of the original process. An improved sintering process and a new process of pressing, sintering, quenching, and low-temperature tempering were applied to Fe-1.8Ni-0.5Mo-1.2Cu-0.2C prealloyed powder. The pearlite quantity in the prepared gear is 60, and the new prepared gear comprises tempered martensite and ferrite subsequent to heat treatment. The impact toughness improved from 9.8 J/cm² to 15.2 J/cm².

Using standard stretch spline as the research object, the influence of gas counter pressure (GCP) and GCP holding time on melt-foaming behavior in chemical foaming injection molding (CFIM) process was investigated. Based on the results obtained from the experiment, the critical GCP pressure under which melt flow front cell was not cracking, the critical GCP pressure under which melt was not foaming, and the pressure release time of melt second foaming were proposed. Finally, the influence mechanism of GCP technology on melt foaming action during CFIM process was revealed.

This paper analyzes the chemical composition and structural characteristics of the fly ash in the Jining area, and how it could improve the performance of the anticorrosive coating of polyolefin adhesive tapes with a focus on the influence of the fly ash content on their mechanical properties. The experimental results show that the fly ash is mainly composed of SiO₂, Al₂O₃, and Fe₂O₃, the total mass fraction of which is approximately 88.04%. The mass fraction of CaO is 12.40%. The fly ash is an alkaline ash with a small amount of amorphous vitreous bodies and certain crystal minerals such as quartz, mullite, and hematite in it. Subsequent to adding fly ash, the mechanical properties of the anticorrosive coating of polyolefin adhesive tapes are improved. Subsequent to adding 15 batches of fly ash, the mechanical properties of the test sample are optimal with its tensile strength being 91.93 N/cm. Furthermore, the elongation at fracture is 536.67%, and the peel strength is 33.43 N/cm. Fly ash is an excellent filler that can replace calcium carbonate in the production of the anticorrosive coating of polyolefin adhesive tapes. The study can not only improve the utilization and added value of fly ash, improving the properties of the anticorrosive coating of polyolefin adhesive tapes, but it can also provide a theoretical basis for industrial applications of industrial fly ash in rubber reinforcement.

To investigate the energy saving effect of servo press in stamping production, the energy consumption and the slide power of a 6300 kN multi-link mechanical servo press used in the stamping production of washing machines were quantitively measured, and the energy consumption was calculated and analyzed. The results showed that the single energy consumption of the tested press was 0.094 5 kW·h, and the single specific energy consumption was 15.0×10^-6 kW·h/kN. The energy transfer efficiency from the machine input to the slide was 39.5%. Based on these results, the single energy consumption of the tested press was observed to be 86.4% lower than that of the traditional 8000 kN hydraulic press replaced, and the energy transfer efficiency was at least 25% higher than that observed in the literature data. Furthermore, along with its high shaping performance, the proposed method of using servo press technology has also achieved remarkable energy saving effect.

Focusing on the optimization of a building-type natural gas distributed energy system, in this study，the dynamic electric load averaging algorithm and multidimensional iterative algorithm were combined to determine the capacity of a basic generator set. The optimal power range of the generator set was determined to be 2297~2477 kW. Results of the analysis of the project’s energy consumption showed that the primary energy saving ratio of the optimized model increased by 14.3%, the economic cost of energy increased by 20.14%~20.85%, and the comprehensive energy utilization rate was greater than 70%.

The demand for urban railways is increasing with the expansion of the scale of urban rail transit, resulting in a high requirement with respect to the operation quality of urban rail transit services. Given the demand of passengers, this study establishes a mixed integer model to minimize the total passenger waiting time and operational cost of the urban rail system. An annealing algorithm is simulated to design the train timetable and rolling stock schedule for a certain route, and calculations and examples are used to analyze their feasibility. The results denote that the proposed model can be used to design a proper train timetabling and rolling stock scheduling plan based on the passenger demand.

In this study, the integrated vehicle and crew scheduling problem of express buses on high-speed railways is studied owing to the lack of appropriate operational approaches for this new type of public transport service product. To benefit from the flexibility of express buses for high-speed railways, the work-time window constraint is introduced to meet the work-time requirements of the crew. An integrating optimization model for vehicle and crew scheduling is built. Then, the optimal vehicle and crew scheduling program is validated with real-time examples. Results show that this integrated optimization model is better than the traditional multiple route optimize independently. Operating costs are reduced by approximately 8.98% compared with the original operation schedule and approximately 4.73% compares with the independent optimization using this integrated optimization model, while the number of crew is also reduced. Furthermore, the accuracy and the satisfactory results of the model in solving the integrated vehicle and crew scheduling problem of express buses for high-speed railway are verified herein.

In reality, the ride-hailing market is characterized by randomness, and the static pricing strategy of the platform cannot adjust to instantaneous imbalances in the system between available driver supply and passenger demand. To this end, from the dual perspective of the government and ride-hailing platforms, the platform dynamic pricing strategy based on social welfare and profit maximization is studied in terms of the platform, drivers, and passengers. The queuing theory and the birth-death process are used to describe the flow process of drivers in ride-hailing platforms, and the social welfare maximization and platform profit maximization model under dynamic pricing is constructed by introducing the psychological expected price curve of passengers and drivers. The Brouwer fixed-point theorem is used to examine the existence of the model solution. Based on the sequential quadratic programming method, the algorithm is used to solve the model, and the platform pricing and driver profit-sharing to maximize social welfare and platform profit of the ride-hailing system are obtained and compared. Research shows that the established model not only calculates the optimal pricing strategy of the platform but also analyzes the impact of changes in basic parameters (average ride time, expected passenger/driver psychological price distribution, etc.) on the pricing strategy of the platforms.

In this paper, the total intersection delay time index and the single direction maximum delay time index are proposed.A simplified congestion evaluation index model is established using data acquired from navigation software regarding road condition, queue length, and the number of lanes at each entrance. The applicability of the model is verified against examples of intersections of Beijing. The congestion level of the example intersections is ranked on the basis of the total delay time index and the single direction delay time index.The result is consistent with the actual data. When compared with traditional intersection evaluation indexes, the intersection delay time index fully utilizes big data from navigation software to avoid tedious onsite investigation, has strong scalability in operation and practicability, and provides more reliable theoretical support to urban managers in the decision-making process of intersection reconstruction.

Based on DMSP/OLS night-time light remote sensing imagery, the authors selected four years from the fourteen-year period of 2000 to 2013 to perform image acquisition and correction and extract data including the total amount of the light and the area of the light. Based on the annual growth of the light data, the differences among regions in the country were analyzed, and the correlation analysis was performed with regard to air pollutants. Experimental results show that：(1) As a whole, the amount of night-time light has increased nationwide, and the range of increase was affected by the policies of the relevant year. (2) There is a positive correlation between the total amount of night-time light and the air pollutants, and the correlation coefficient between the two is high. The correlation between industrial air pollutants and night light is decreasing, whereas the correlation between domestic air pollutants and night light is increasing. (3) The consistency between the total amount of night-time light and air pollution high/high concentration area has steadily enhanced. In this paper, we combine the night-time light imagery data and air pollution data to explore the temporal and spatial evolution of air pollutants through the comparison of the variations of night-time light data and provide a novel perspective for the comprehensive treatment of air pollution in China.

Polyferric titanium water purification agent (I-PTF) was prepared from ilmenite and its microscopic properties were analyzed using scanning electron microscopy and X-ray diffraction. The water purification effect and sludge settling performance of I-PTF were studied through beaker and sludge settling experiment. The morphology of sludge was observed using a fluorescence microscope. Results showed that the removal rate of CODCr by I-PTF was better than polyaluminium chloride (PAC). When the dosage was 168 mg/L, the removal rate of COD_Cr by I-PTF was 22%,and it was higher than that of PAC. Compared with PAC, the sludge volume reduction rate by I-PTF was more than 80%, and its settling speed was faster. The settling could be completed in approximately 11 minutes. The flocs formed using I-PTF were more compact and the boundary was clearer.

To comprehensively monitor and analyze the distribution of chloride concentrations in river water as well as to understand its effect on environmental quality monitoring in Dongying, the chloride concentrations in 38 river sections of Dongying were continuously monitored in 2018. The results showed that the monthly chloride concentrations in six sections were less than 1000 mg/L, twenty sections’ concentrations were in the range of 1000~2000 mg/L, six sections’ concentrations in the range of 2000~3000 mg/L and the remaining six sections’ concentrations above 3000 mg/L. This indicates that the river water of Dongying has high chlorion content; the concentration of chlorion also greatly varied with the location of the sections (upstream or downstream) and the time of sampling. Chloride can cause positive interference to certain monitoring items or lead to the inapplicability of certain monitoring methods, especially for COD, ammonia nitrogen, permanganate index and other items. Therefore, the influence of chlorion on environmental quality analysis must be carefully considered, and a series of measures must be taken to eliminate the influence of chloride during water quality monitoring for the rivers of Dongying.

A method was established for the determination of genotoxic impurity.in erlotinib hydrochloride(3-ethynylaniline) using liquid chromatography-mass spectrometry. Using the ESI ion source positive ion multireaction monitoring (MRM) mode,the ion pairs 118→75 and 118→91 were selected and measured. The chromatographic column was Thermo Hyperiil GOLD C8(100 mm×4.6 mm,3 μm),the mobile phase was methanol and waterfor gradient elution,the flow rate was 0.4 mL/min,and the column temperature is 35℃.Results showed that the detection mass concentration of 3-ethynylaniline in this method had a good linear relationship in the range of 1.0 to 20 ng/mL, with R²=0.999 4.The relative standard deviation(n=6) of the precision experiment was 1.13%,and the recoveries of standard additions (n=3) at low,medium,and high concentrations were between 90.1% and 106.1%.The method exhibited high sensitivity,specificity,and precision,and it met the requirement for the determination of 3-acetyleniline,a genotoxic impurity in erlotinib hydrochloride tablets.

A microsample pH meter was prepared by modifying Iridium oxide thin film on a microelectrode using an electrochemical method. In the measurement process, the potential difference between the test and reference electrode was determined by dropping only approximately 3~5 μL solution on the electrode which with small volume. Then, data was obtained using a data acquisition card. The potential difference signal is converted into a digital signal, and the pH value is output with the Matlab software fitting curve. The measurement results of microsample pH meter are consistent with those of commercial pH meters. The electrode is convenient,and high sensitivity and good reproducibility, and it has superiority in the analysis of rare and expensive samples biological samples. Therefore, it has broad development prospects.

The outbreak of COVID-19 has caused serious harm.The rapid diagnosis and precise treatment of COVID-19 are major challenges currently facing. In this paper, the clinical application of blood lactic acid index and blood lactic acid biosensors in recent years were reviewed. It is suggested that blood lactic acid level or blood lactate clearance is an important biochemical indicator for the severity stratification, evaluation of clinical therapeutic effect and prognosis of the disease. POCT blood lactic acid biosensor technology is fast, economical and realiable,which can realize the rapid and continuous diagnosis of blood lactic acid in clinical patients or indiciduals (family),and it is conducive to the severity stratification and evaluation of clinical therapeutic effect. It also helps patients identify their own condition in time, relieve psychological concerns, and promote physical recovery.

Using network open data, Auto CAD 2008, Sun Analysis 7.5, and PHOENICS 2011, a 3D model of buildings in Wuhan Leishenshan Hospital and its surrounding areas are established to perform the simulation and superposition analysis of sunlight ultraviolet rays and wind environment, which lays a foundation for the establishment of prevention and control early warning mechanism. Results show that the overall outdoor ground height of the hospital exhibits good sunlight and ultraviolet sunshine environment. During the winters and springs, the overall wind speed at the outdoor pedestrian height in the isolated medical area is not good. The wind speed in the medical and nursing living area and the comprehensive logistics area is conducive to the natural dissipation of pollutants in winters; however, it is not good during the springs. Under the working conditions during winters and springs, the wind pressure difference on the building surface of the medical living area and the logistics support area is conducive to the indoor natural ventilation as a whole. Therefore, it is still necessary to conduct daily cleaning and disinfection and perform key epidemic prevention work, as well as the outdoor detection of the virus.

In view of the development status of medical protective clothing in China, the important performance and standard of disposable medical protective clothing in recent years are systematically reviewed. Barrier antibacterial , antimicrobial and antistatic properties are important properties of disposable medical protective clothing, which can be improved by such as fiber modification, blending and coating finishing agent. The performance standard of medical protective clothing is constantly improved and refined, but the requirements for convenience and comfort are still lacking. Textile-based flexible sensors have a broad application prospect in realizing the intellectualization of medical protective clothing, but the problems such as preparation cost, use efficiency and wearability are still huge challenges.

Considering the current situation fighting against the COVID-19 and the demand for medical masks in China, the technical standards, preparation technology, protective effectiveness and development of medical masks were summarized in this paper. The advantages of various medical masks in protective performance were also analyzed and compared，then the reasonable suggestions on the application scope of masks were proposed. Results show that GB 19083—2010 medical protective masks with electret treatment have the highest filtering efficiency compared to other types of medical masks, which is not less than 95%. It is suitable for the protection of medical personnel and related staff in the department of infectious diseases or virus. However, there are still some problems such as poor air permeability and no antibacterial property. In the analysis, the new type of medical masks with high antibacterial, high resistance to virus and comfortable wearing are the most desirable properties in the near future.

To pre-estimate the full-scale fishing ship resistance, this paper takes a 11.75 m fishing ship as the research object,and a complete set of methods is developed to convert the numerical simulation result of the ship model to a full-scale ship based on the CFD method. The results denote that this method can effectively estimate the hull resistance of the fishing ships and reduce the design cost. Based on the vertical hydrodynamic of the ship, the reasons for the peak point and valley point on the curve of the resistance are analyzed explaining the manner in which the resistance increases initially and subsequently decreases with increasing speed of the ship.