Science and technology (S&T) powerhouse provinces and China as an S&T powerhouse together constitute a coordinated transmission system of “provincial-level practice-national strategy”, serving as an important support for advancing China’s science and technology modernization. This study employs the visualization tool CiteSpace (version 6.1.R6) to conduct a knowledge graph analysis of 795 relevant articles indexed in core journals within the China National Knowledge Infrastructure(CNKI) database from 2006 to 2025. Using keyword co-occurrence analysis, cluster analysis, and burst-term detection, the study systematically examines research hotspots and evolutionary trajectories in this field. The findings indicate that domestic studies mainly focus on four themes: strategic coordination, technological breakthroughs, innovation ecosystems, and digital-intelligent transformation. The research paradigm demonstrates a full-chain, integrated evolution: “national strategy-regional implementation-technology application-ecosystem optimization”. Future research should place greater emphasis on differentiated provincial pathways, interdisciplinary integration, and international comparative studies to further deepen the development of this field.