白藜芦醇对阿司咪唑诱导斑马鱼心脏损伤的保护作用

doi:10.3976/j.issn.1002-4026.2015.03.006

Abstract

Abstract: We explore the protection effect of different concentrations resveratrol to astemizoleinduced cardiac injury of zebrafish embryos.We treat zebrafish embryos with 4 μmol/L astemizole and different concentrations resveratrol with normal growth 48 hpf zebrafish embryo as an experimental model.We observe cardiac phenotypes, heart rates and the variation of SVBA at 72 hpf. Astemizole group shows heart injury such as pericardium edema, blood cell accumulation around the heart, heart rate reduction and SVBA interval shortening after drug feeding. However, astemizoleinduced heart toxicity significantly decreases with the increase of resveratrol concentration for resveratrol group.We therefore think resveratrol can protect astemizoleinduced cardiac injury of zebrafish embryos.

Key words: cardiac injury, heart rate, astemizole, resveratrol, protection, zebrafish

CLC Number:

R965.1

XUE Di, HAN Liwen, YANG Jifang, HE Qiuxia,WANG Xue,HOU Hairong，ZHANG Aiping, LIU Kechun. Protection effect of resveratrol to astemizoleinduced cardiac injury of zebrafish embryos[J].SHANDONG SCIENCE, 2015, 28(3): 29-33.

References

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Protection effect of resveratrol to astemizoleinduced cardiac injury of zebrafish embryos

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