基于气相色谱的六神系列制剂中人工麝香的特征图谱和含量测定研究

doi:10.3976/j.issn.1002-4026.2025021

Abstract

Abstract: A scientific, unified, and reliable characteristic chromatograms and determine the content of artificial musk in the Liushen series of preparations was established using Gas Chromatography (GC) to accurately reflect its quality, providing an experimental basis for subsequent revisions of quality standards. The similarity of characteristic chromatograms from 39 batches of Liushen series preparations was analyzed using Traditional Chinese Medicine Chromatographic Fingerprint Similarity Evaluation Software (2012 version), with similarities all above 0.995. Liushen pills exhibited 5 characteristic peaks, while Liushen capsules showed 4, one of which was identified as muscone. The content of artificial musk in three types of preparations was determined, with muscone showing a good linear relationship within the range of 0.0064~0.6388 mg·mL-1(R=0.999). The average recovery rates(n=6)andRSD%for pills, capsules, and gel agents were 102.3% (1.0%), 97.3% (1.5%), and 103.1% (1.6%) respectively. The established GC characteristic chromatograms and content determination method can comprehensively reflect the quality of artificial musk in LiuShen series preparations and can be used for quality control of artificial musk in these preparations.

Key words: Liushen series preparations, artificial musk, muscone, characteristic chromatograms, gas chromatography, content determination

CLC Number:

R284.2

GUO Lumei, WANG Yingchao, ZHANG Zhenkai, LIU Xingpeng, CHEN Feng. Characteristic chromatograms and content determination of artificial musk in Liushen series preparations based on gas chromatography[J].Shandong Science, 0, (): 1-.

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Characteristic chromatograms and content determination of artificial musk in Liushen series preparations based on gas chromatography

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