黄芩及其有效成分治疗溃疡性结肠炎机制研究进展

doi:10.3976/j.issn.1002-4026.20240017

Abstract

Abstract:

Ulcerative colitis (UC) is an inflammatory bowel disease characterized by persistent mucosal inflammation.Scutellaria baicalensis (also known as Huangqin), as a common traditional Chinese medicines used in clinical practice, is known for its efficacy at clearing internal heat,eliminating dampness, purging fire,eliminating toxins, stopping bleeding, and calming fetal activity. Its formulations, including Huangqin Decoction, Peony Decoction, and Pueraria, Scutellaria, and Coptis Decoction, are often used to treat damp-heat UC. Studies have shown that S. baicalensis and its active ingredients play an important role in protecting the intestinal mucosa, and have anti-inflammatory and immunomodulatory effects. This study reviews the mechanism of action of S. baicalensisand its active ingredients (baicalin,baicalein,oroxindin, wogonin, Scutellaria baicalensis polysaccharide, etc.) in the treatment of UC in recent years, including the protection and repair of the intestinal mucosal barrier, the active ingredients anti-inflammatory and immunomodulatory properties, effects against antioxidative stress, and regulation of intestinal flora, to provide a reference for targeted clinical treatment of UC and drug development.

Key words: ulcerative colitis, Scutellaria baicalensis, active ingredient, mechanism of action

CLC Number:

R285

LUO Yaqin, HUANG Wei. Progress in the research on the mechanism of action of Scutellaria baicalensis and its active ingredients in treating ulcerative colitis[J].Shandong Science, 2024, 37(2): 20-28.

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Progress in the research on the mechanism of action of Scutellaria baicalensis and its active ingredients in treating ulcerative colitis

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