Abstract:

The dynamic changes of ephedrine hydrochloride,pseudoephedrine hydrochloride,asarinin,benzoylaconitine, benzoylaconitine and benzoylaconitine in Mahuang Xixin Fuzi Decoction during the extraction process were studied. HPLC was used to determine the content changes of six active ingredients in the water extract at different times. According to the dissolvingout amount and transfer rate, the dissolution amount of six active ingredients in the first 90 minutes showed an upward trend, and the composition was stable. After 90 minutes, the growth trend of dissolution rate slowed down and there were different degrees of depletion, and the components existed in unstable state. The extraction process of Mahuang Xixin Fuzi Decoction can be extracted by water and boiling for 90 minutes, which can ensure the stable existence of the efficacy index components and the maximum dissolvingout amount.

Key words: decocting time, active ingredient, Mahuang Xixin Fuzi Decoction, dynamic change