丁姜和胃膏贴剂体外透皮释药研究

doi:10.3976/j.issn.1002-4026.2017.05.006

Abstract

Abstract:

The in vitro transdermal diffusion cell method was applied, the abdominal skin of rats in vitro was taken as the barrier, and the content determination of eugenol in transdermal solution of Dingjiang Hewei plaster and the cumulative release amount of transdermal drug per unit area in different time periods were researched. Experimental results showed the chromatographic conditions were as followed: Agilent Zorbax SB-C18 column (150 mm×4.6 mm, 5 μm), methanol-water(65∶35, V/V) as mobile phase, detection wavelength was 280 nm, the RSD of the repeatability of eugenol content was 0.932%, the RSD of sample solution stability within 24 h was 1.843%, the average recovery was 97.4192％，and its RSD was 1.426％. Eugenol transdermal drug release showed a trend of first fast, then slow. The total cumulative drug release within the first 10 h accounted for 76.71% of the total cumulative drug release within 20 h, while the accumulative release total amount within 10～20 h was only 23.29%.

Key words: isolated rat skin as barrier, Dingjiang Hewei plaster, cumulative transdermal amount per unit area, in vitro transdermal diffusion cell method, the content determination of eugenol

CLC Number:

R284.1

ZHANG Wei，CAO Jia，WANG Hui，CAO Yun-fei，WANG Wei. Study on in vitro transdermal drug release of Dingjiang Hewei plaster[J].SHANDONG SCIENCE, 2017, 30(5): 32-36.

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Study on in vitro transdermal drug release of Dingjiang Hewei plaster

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