复方葛根片对衰老大鼠胸主动脉损伤的保护作用

doi:10.3976/j.issn.1002-4026.2016.05.010

Abstract

Abstract:

We divided rats into model group and normal group, and high, middle and low dose group of compound puerarin tablet to investigate the impact of compound puerarin tablet on D-galactose induced serum homocysteine (Hcy) level and protective effect on thoracic aorta injury of aged rats. We employed subcutaneous D-galactose injection to establish rats aging model, AU5800 automatic biochemical analyzer to detect Hcy content in rats serum, and SPSS16 to analyze Hcy content and weight difference of each group. We also performed HE staining to rats thoracic aorta and observed its pathological changes with a light microscope. Results show that significant difference (P<0.01) exists in Hcy level and weight of model group and normal group, each dose group and model group. Different dose groups have different protective effects on thoracic aortic vessels, especially for the high dose group having best protective effect. We discover that compound puerarin tablets can reduce Hcy levels in D-galactose induced old rats serum and have protective effects on vascular injury of thoracic aorta.

Key words: D-galactose, Homocysteine, aged rat

CLC Number:

R285.5

LI Yunjiang，SUN Lin，BI Yunsheng，ZHANG Shuyu，YU Yanli. Protective effect of compound puerarin tablet on thoracic aorta injury of aged rats[J].SHANDONG SCIENCE, 2016, 29(5): 60-64.

References

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Protective effect of compound puerarin tablet on thoracic aorta injury of aged rats

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