Abstract:

      Zebrafish embryo is highly sensitive to chemical exposure and has much unique superiority over other animal models, so it is widely applied in toxicology. Besides chemical concentration, many other influences, such as chorion barrier, embryo exposure time, chemical characteristics and the interaction between different chemicals, should also be considered. Assessment methods of embryo toxicity are evolving from morphologic observation to molecular research, more emphasis on chemical mechanism. This makes zebrafish embryo have higher specificity and sensitivity in the toxicity detection.

Key words: zebrafish, embryo, toxicity