Shandong Science ›› 2025, Vol. 38 ›› Issue (5): 1-9.doi: 10.3976/j.issn.1002-4026.20240118

• Traditional Chinese Medicine and Natural Active Products •     Next Articles

Quantitative analysis of seven major ginsenoside components of Panaxquinquefolius L. from different origins

ZHU Henga,b(), DING Huia,b, WANG Xiaoa,b, LI Lilia,b,*()   

  1. a. Shandong Engineering Research Center for Innovation and Application of General Technology for Separationof Natural Products, Shandong Analysis and Test Center; b. Key Laboratory for Natural Active Pharmaceutical Constituents Research in Universities of Shandong Province,School of Pharmaceutical Sciences, Qilu university of Technology (Shandong Academy of Sciences), Jinan 250014, China
  • Received:2024-10-14 Revised:2024-12-26 Published:2025-10-20 Online:2025-10-11

Abstract:

Panaxquinquefolius L. is a medicine-food homology used in traditional Chinese medicine,of which ginsenosides are an important active component.The ginsenoside content of Panaxquinquefolius L. is closely related to its quality. Due to the effects of the geographical environment,the ginsenoside content of Panaxquinquefolius L.from different origins varies. Based on liquid chromatography-mass spectrometry,this study established a quantitative analysis method for seven major ginsenoside components,through which the content of 27 batches of samples from domestic and foreign origin swasanalyzed. The results showed that the contents of ginsenosides Rb1,Re,Rg1,Rd,Ro,and the pseudoginsenoside F11 were highest in the Panaxquinquefolius L. produced in Canada. The contents of the ginsenosides Rb1,Rg1,Rd,and Ro in the Panaxquinquefolius L. produced in the United States were higher than those from the three domestic production origins (Jilin,Shandong,and Liaoning province). The contents of the ginsenoside Re and the pseudoginsenoside F11 in Panaxquinquefolius L.produced in Shandong were higher than those produced in the United States. The contents of the rare ginsenoside Rg3 in the Panaxquinquefolius L. produced in Jilin and Liaoning were higher than that of the United States and Canada. This study revealed the differences in the content of seven ginsenosides in Panaxquinquefolius L. with foreign and domestic production origins,thereby providing technical support forquality control and improving quality standards for Panaxquinquefolius L.

Key words: Panaxquinquefolius L., ginsenosides, multi-component content testing, ultra-high-performance liquid chromatography high-resolution mass spectrometry

CLC Number: 

  • R284.1