Abstract: We employed medical highconcentration alcohol reflux to extract androsin. We optimized extraction conditions with L9(34) orthogonal design and androsin yield and content as main indexes. Experimental results show that the optimal extraction scheme is A1B3C3, 3 times reflux extraction for 4.5 h with 95% alcohol of 20 times medical amount (10 times amount reflux for 2 h for the first time, 6 times amount reflux for 1.5 h for the second time, and 4 times amount reflux for 1 h for the third time).

Key words: androsin, orthogonal experiment, Picrorhiza scrophulariiflora Pennell, extraction with alcohol