Abstract:

 We optimized Psoraleae corylifolia L. and Salvia miltiorrhiza Bge. extraction process of ethanol extraction group in Bushen Huoxue Granule. We also optimized ethanol concentration, ethanol dosage, extraction time and extraction times in extraction process with orthogonal experiment and contents of Isopsoralen in Psoraleae corylifolia and Tanshinone II A in Salvia miltiorrhiza as evaluation indexes. Experimental results show that optimum extraction conditions are 12 times 70% ethanol and three extraction times, one and a half hours per time. The extraction process is simple, reasonable, accurate and practicable, and provides necessary conditions for subsequent optimization of water extraction and granulation process.

Key words: orthogonal experiment, isopsoralen, extraction process, Bushen Huoxue Granule, tanshinone IIA