基于响应面设计的头孢他啶母液冷冻浓缩工艺优化

doi:10.3976/j.issn.1002-4026.2021.05.015

Abstract

Abstract: Using ceftazidime mother liquor as the raw material, we recovered its effective components using suspension freeze concentration technology. Based on single factor test data, taking the recovery rate of ceftazidime as the evaluation index, we used the Box-Behnken response surface method to analyze the three extraction conditions of freezing temperature, freezing time, and stirring rate in three levels respectively to optimize the extraction conditions. The optimum recovery conditions of ceftazidime were as follows: freezing temperature -7 ℃, freezing time 3 h, stirring rate 20 r/min. Results show that the recovery of ceftazidime under these conditions was 93.15%.Combined with the actual production situation, the optimized suspension freeze concentration process is stable and can shed light on the follow-up study of ceftazidime.

Key words: ceftazidime, freeze concentration, response surface method, suspension crystallization freeze concentration

CLC Number:

R978.1

JIA Quan, HU Li-min, REN Feng, ZHANG Jian-li, TIAN Hong-nian, LIU Shu-bin. Optimization of the freeze concentration process of ceftazidime mother liquor based on the response surface method[J].Shandong Science, 2021, 34(5): 121-129.

References 13

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Optimization of the freeze concentration process of ceftazidime mother liquor based on the response surface method

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