Abstract: We aimed to investigate the mechanism of Huangqi Liujunzi decoction in the treatment of COVID-19 based on Network Pharmacology.The chemical components and targets of Huangqi Liujunzi decoction were collected from the databases of TCMSP, Pubchem, and Swiss Target Prediction and standardized using the Uniprot database.COVID-19 related genes were obtained by the GeneCards database,and we further mapped the common genes of disease and drugs.The protein-protein interaction data were downloaded from the STRING database, and the components-key targets visual network graph and protein interaction network were constructed using Cytoscape software to screen out the core targets.The GO function and KEGG pathway enrichment were analyzed by R language algorithm, and the target-pathway network was constructed using Cytoscape software.The results showed that 145 compounds and 1618 corresponding targets were screened. The key active components included luteolin,kaempferol,nobiletin,naringenin,baicalein, and acacetin.The key targets included MAPK1/3/8/14,CASP3/8,IL6/1β,ALB,apoptosis regulatory protein,PTGS2,protooncogene, and protooncogene of REL.GO function enrichment analysis included 1421 biological processes, 63 molecular functions, and 36 cell components;KEGG pathway enrichment analysis revealed 41 pathways, including PI3K-Akt signaling pathway, apoptosis, endocrine resistance,MAPK signaling pathway,Toll-like receptor signaling pathway,and osteoclast differentiation.Huangqi Liujunzi Decoction has a therapeutic effect on COVID-19 through antiviral, anti-inflammatory, and immune regulation mechanisms. 

Key words: Huangqi Liujunzi decoction, COVID-19, network pharmacology, antiviral, anti-inflammatory