网络药理学和斑马鱼模型在中药药效物质及作用机制研究中的应用进展

doi:10.3976/j.issn.1002-4026.20240014

Abstract

Abstract:

Network pharmacology, which is highly consistent with the holistic and systematic perspectives of traditional Chinese medicine (TCM) with its multiple components and targets, has rapidly developed in the modernization of TCM. Experimental verification is one of the key contents of network pharmacology research. The zebrafish model has a complete system of drug metabolism, as well as a complex in vivo environment and target and pathway regulation mechanisms. Experiments that utilize this model have the advantages of low drug dosage, high throughput, and short cycle time. In recent years, the research mode that combines network pharmacology prediction with experimental validation using the zebrafish model has been widely applied to elucidate the effective substances and mechanisms of action of TCM. This study reviews the progress and development trends in the comprehensive application of network pharmacology and zebrafish modeling, aiming to provide a reference for their application in elucidating the modern scientific implications of the efficacy of TCM.

Key words: network pharmacology, zebrafish, traditional Chinese medicine, effective substances, mechanism, quality markers

CLC Number:

R285.5

LIU Kechun, WANG Yongcheng, ZANG Xiaohan, XIA Qing, ZHANG Yun, ZHANG Shanshan, SUN Chen. Advancements in network pharmacology and zebrafish modeling for studying traditional Chinese medicine’s effective substances and mechanisms of action[J].Shandong Science, 2024, 37(2): 29-35.

Figures/Tables 2

References 34

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Advancements in network pharmacology and zebrafish modeling for studying traditional Chinese medicine’s effective substances and mechanisms of action

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