绵萆薢的化学成分研究

doi:10.3976/j.issn.1002-4026.20240071

Abstract

Abstract:

The chemical compositions of Dioscorea spongiosa were investigated using macroporous resin, MCI column chromatography, gel column chromatography and preparative liquid chromatography. The structures of the isolated compounds were identified by ¹H-NMR, ¹³C-NMR, ESI-MS. Ten compounds were isolated from Dioscorea spongiosa, which were identified as three aromatic compounds: diosniponol C (1), 3,5-dihydroxy-4,4'-dimethoxybibenzyl (9), P-hydroxyphenyl butanone (10);two saponin analogues: methyl protodioscin (2), protogracillin (6); three diarylheptanoids: (3R,5R)-3,5-dihydroxy-1,7-bis-(4-hydroxy-3-methoxyphenyl)-heptane 3-O-β-D-glucopyranoside (3), (3R,5R)-3,5-dihydroxy-1,7-bis(4-hydroxyphenyl)heptane 3-O-β-D-glucopyranoside (4), (3R,5R)-3,5-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)heptane 3-β-D-glucopyranoside (5); one alkaloid: cyclo(l-Pro-l-Leu)(7); one sterols: β-sitosterol(8), of which compounds (3~5),(7),(9) were isolated from Dioscorea spongiosa for the first time. In this study, the chemical constituents of 70% ethanol extract of Dioscorea spongiosa were systematically isolated, which enriched the chemical composition and laid the foundation for the comprehensive development of Dioscorea spongiosa.

Key words: Dioscorea spongiosa, chemical constituents, structural identification

CLC Number:

LIU Wei, YU Jinqian, DONG Hongjing, BOTIROV Erkin Khozhiakbarovich, GUSAKOVA Svetlana Dmitrievna, WANG Xiao. Studies on the chemical constituents of the Dioscorea spongiosa[J].Shandong Science, 2025, 38(4): 8-13.

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Studies on the chemical constituents of the Dioscorea spongiosa

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