牡丹籽油微囊粉对异烟肼诱导的斑马鱼发育毒性的保护作用

doi:10.3976/j.issn.1002-4026.2021.04.008

Abstract

Abstract: To evaluate the protective effect of peony seed oil microcapsule powder (PSO) on the developmental toxicity of isoniazid (INH). Zebrafish embryos developed to 2 h were treated with various concentrations of PSO. The mortality rate, hatching rate, and morphological changes of the juvenile fish were observed at 24, 48, 72, and 96 h after treatment to determine the tolerance dose of PSO to zebrafish. The protective effect of PSO on INH-induced developmental toxicity in zebrafish was evaluated by mortality and morphological scoring.The results showed that PSO at 20, 40, 80 μg/mL concentrations had no effect on zebrafish development. At a concentration of 20 μg/mL, PSO alleviated deformity and mortality rates of juvenile zebrafish caused by INH. PSO had a protective effect on INH-induced developmental toxicity.

Key words: peony seed oil microcapsule powder;isoniazid, zebrafish, developmental protection

CLC Number:

R285.5

ZOU Hong-yuan, ZHU Cheng-yue, ZHANG Shan-shan, KONG Rui-qi, ZHANG Yun, LIU Ke-chun. Protective effect of peony seed oil microcapsule powder on isoniazid-induced developmental toxicity in zebrafish [J].Shandong Science, 2021, 34(4): 45-51.

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Protective effect of peony seed oil microcapsule powder on isoniazid-induced developmental toxicity in zebrafish

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