Abstract:

Through pharmacological study on Tonglishu Granule, its therapeutic effects on acute gouty arthritis were evaluated. A rat model of acute gouty arthritis induced by sodium urate was established. Tonglishu Granules were given 3.24,6.48 ,12.96 g/kg respectively to investigate the improvement of ankle swelling degree; The pain threshold of mice was determined by hot plate method, and Tonglishu Granules were given 4.68，9.36,18.72 g/kg to evaluate the painrelieving effect; To establish a model for auricle swelling in mice induced by croton oil, Tonglishu Granules were given 4.68, 9.36, 18.72 g/kg to observe its antiinflammatory effect. The results showed that Tonglishu Granule could improve the degree of ankle joint swelling in rats and reduce the levels of inflammatory factors TNFα and IL6, and improve the pain threshold of mice measured by hot plate method, which had certain analgesic effect. Tonglishu Granule also had certain antiinflammatory effect on croton oilinduced ear swelling in mice.

Key words: Tonglishu Granule, hot plate method, acute gouty arthritis, ear swelling, rat model