基于疏肝解郁功效的逍遥散寒苦肝和温辛肝性效关系研究

doi:10.3976/j.issn.1002-4026.2022.01.006

Abstract

Abstract:

The purpose of this study was to explore the internal relationship between temperature differences and efficacy of Traditional Chinese Medicine Xiaoyaosan,used for soothing liver and relieving depression. The main active ingredients and targets of the combination of cold bitter and warm pungent medicinal properties were obtained by database retrieval. The protein-protein interaction network was constructed based on STRING platform, and Kyoto encyclopedia of genes and genomes pathway and statistical analysis of the identified medicinal properties' combination protein-protein interaction network were carried out using metascape. The results show that the liver meridian properties of Xiaoyaosan were mainly involved in neurotransmitter, signal pathway, and endocrine pathway through HTR2B and other targets, and the cold bitter medicinal properties of Xiaoyaosan were mainly involved in energy metabolism and inflammatory reaction through CREBRF and other targets. The warm pungent medicinal properties of Xiaoyaosan was mainly involved in inflammatory reaction, neuronutrition, and amino acid metabolism through ADCY5 and other targets, thereby soothing the liver and relieving depression. The study explained the common characteristics of the liver meridian medicinal properties and specific characteristics of cold bitter medicinal properties and warm pungent medicinal properties from the molecular network level in Xiaoyaosan, and provided new ideas and new methods for the study of the internal relationship between the medicinal properties and efficacy of Xiaoyaosan.

Key words: drug combination, protein-protein interaction, network functional module, soothing the liver and relieving depression, Xiaoyaosan

CLC Number:

R285

SHI Jian-ru,GAO Yao,ZHAO Hui-liang,TIAN Jun-sheng,WU Yan-fei. Nature-effect relationship research of cold bitter and warm pungent medicinal properties of Xiaoyaosan for soothing the liver and relieving depression based on nature combination[J].Shandong Science, 2022, 35(1): 37-44.

Figures/Tables 7

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References 28

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药性组合	基因名	药性组合	基因名
逍遥散中寒苦肝药性	AR	逍遥散中温辛肝药性	SCN5A
	ADORA1		SCN10A
	PGR		IL1B
	SCN5A		ADORA1
	ESR1		KCNA5
	KCNA5		ADH1C
	SCN10A		RAPGEF2
	KCNQ1		KCNK4
	CACNAD1		FADD
	···		···
	NPPA		NPPA

药性组合	通路数目	通路
温辛药性和寒苦药性	1	胰导素抵抗
		神经活性配体-受体相互作用
温辛药性和归肝经药性	3	cAMP信号通路
		胆碱能突触
寒苦药性和归肝经药性	2	MAPK信号通路
		心肌细胞肾上腺素能信号

Nature-effect relationship research of cold bitter and warm pungent medicinal properties of Xiaoyaosan for soothing the liver and relieving depression based on nature combination

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