J4 ›› 2011, Vol. 24 ›› Issue (3): 22-26.

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SbCl3 catalyzed synthesis of 3,4-Dihydropyrimidinones under solvent-free condition

 MA Jin-Guang1, ZHANG Ji-Ming2, ZHOU Jian-Hua2   

  1. 1.Department of Computer Science and Technology,Binzhou University,Binzhou 256603,China； 2.School of Chemical Engineering,Shandong Polytechnic University,Jinan 250353,China
  • Received:2011-03-15 Published:2011-06-20 Online:2011-06-20

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Abstract:

       We synthesized a series of 3,4-dihydropyrimidinones with SbCl3 as a catalyst and no solvent. The acquired optimal reaction conditions are molar ratio of one aromatic aldehydes, oneβ-dicarbonyl compound and one and a half urea, 0.1 mol catalyst per mol aromatic aldehydes and reaction temperature 70℃. This synthesis method has higher recovery rate and shorter reaction time and can deliver simpler operation, as compared with other traditional Biginelli reactions.

Key words: 3,4-Dihydropyrimidinones, Biginelli reaction, SbCl3, solventfree synthesis

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