Abstract:

       We synthesized a series of 3,4-dihydropyrimidinones with SbCl₃ as a catalyst and no solvent. The acquired optimal reaction conditions are molar ratio of one aromatic aldehydes, oneβ-dicarbonyl compound and one and a half urea, 0.1 mol catalyst per mol aromatic aldehydes and reaction temperature 70℃. This synthesis method has higher recovery rate and shorter reaction time and can deliver simpler operation, as compared with other traditional Biginelli reactions.

Key words: 3,4-Dihydropyrimidinones, Biginelli reaction, SbCl₃, solventfree synthesis