菊苣酸脂质体制备工艺研究

doi:10.3976/j.issn.1002-4026.2020.01.002

Abstract

Abstract: To study the optimal preparation process of chicoric acid liposome, thin-film dispersion ultrasound was used, and the encapsulation efficiency was evaluated to examine the preparation effects. The Box-Behnken design response surface methodology was adopted to optimize the preparation parameters. The results showed that the optimal ratio of phospholipid to cholesterol was 4.20:1, the mass ratio of phospholipid to pharmaceutical was 11.44:1, and the ultrasound time was 6.54 min. The encapsulation efficiency of liposome prepared by the optimal process was 75.18%. The use of Box-Behnken design response surface methodology led to an optimal preparation process, and the obtained process is reasonable and feasible.

Key words: chicoric acid, liposome, response surface methodology , preparation process

CLC Number:

R283.6

WANG Yu-zhen, GAO Shuang, SUN Yue, ZHANG Li, BO Fu-min, FENG An-jie, LI Ling-jun. Preparation process of chicoric acid liposome[J].Shandong Science, 2020, 33(1): 8-15.

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Preparation process of chicoric acid liposome

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