天麻化学成分研究进展

doi:10.3976/j.issn.1002-4026.2016.04.006

Abstract

Abstract:

Gastrodia elata Blume is a valued Chinese herbal medicine that has a long medical history. From 50’s in the last century, researchers have isolated multiple chemical constituents from it, including phenols, organic acids, polysaccharides, steroids, etc. Among the isolated nearly one hundred compounds, phenols and polysaccharides are highlighted, while other trace elements are less involved.Further investigating the relevance between the contents of its active constituents and symbiotic bacteria can guarantee its quality and yield. We review the chemical composition isolated by global researchers and make a prospect and discussion. This provides reference for its better development and utilization.

Key words: gastrodin, chemical composition, Gastrodia elata Blume

CLC Number:

R284.1

LI Yun, WANG Zhi-wei, LIU Da-hui, WANG Xiao, ZHOU Hong-lei. Research advances in chemical constituents of Gastrodia elata Blume[J].SHANDONG SCIENCE, 2016, 29(4): 24-29.

References

［1］中国科学院中国植物志编辑委员会.中国植物志第十八卷兰科［M］.北京:科学出版社,1999: 31.
［2］国家药典委员会.中华人民共和国药典2015年版一部［M］.北京:中国医药科技出版社，2015:58-59.
［3］刘寿山.中药研究文献摘要(1820~1961) ［M］.北京:科学出版社，1963:74.
［4］袁惠南.对天麻所含化学成分香荚兰素论点的疑议［J］.中国药学杂志，1992，27(3)：182-184.
［5］刘星楷，杨毅.中药天麻成分的研究I香荚兰醇的提取与鉴定［J］.上海第一医学院学报,1958(s1)：67-68．
［6］冯孝章，陈玉武，杨峻山．天麻化学成分的研究［J］．化学学报，1979，37 (3)：175-181.
［7］周俊，杨雁宾，杨崇仁．天麻的化学研究I天麻化学成分的分离和鉴定［J］．化学学报，1979，37 (3)：183-189.
［8］周俊，浦湘渝，杨雁宾．新鲜天麻的九种酚性成分［J］．科学通报，1981 (18)：1118 -1120.
［9］TAGUCHI H, YOSIOKA I, YAMASAKI K,et al．Studies on the constituents of Gastrodia elata Blume［J］. Chemical & Pharmaceutical Bulletin, 1981, 29 (1): 55-62.
［10］王莉，肖红斌，梁金淼．天麻化学成分研究 (Ⅰ)［J］．中草药，2003，34 (7)：584-585.
［11］LEE J Y, JANG Y W, KANG H S, et al. Antiinflammatory action of phenolic compounds from Gastrodia elata root［J］. Archives of harmacal Research, 2006, 29 (10): 849-858.
［12］LEE Y K, WOO M H, KIM C H, et al. Two new benzofuran from Gastrodia elata and their DNA topoisomerasesⅠandⅡ inhibitory activities［J］. Planta Med, 2007, 73(12): 1287-1291.
［13］LI N, WANG K J, CHEN J J, et al. Phenolic compounds from the rhizomes of Gastrodia elata［J］. Journal of Asian Natural Products Research, 2007, 9 (3/4/5): 373-377.
［14］张伟，宋启示．贵州大方林下栽培天麻的化学成分研究［J］．中草药，2010，41 (11)：1782-1785.
［15］王莉，王艳萍，肖红斌．天麻化学成分研究（Ⅱ）［J］．中草药，2006，37 (11)：1635-1637.
［16］黄占波，宋冬梅，陈发奎．天麻化学成分研究（Ⅰ）［J］．中国药物化学杂志，2005，15 (4)：227-229.
［17］HUANG Z B, WU Z, CHEN F K, et al. The protective effectsof phenolic constituents from Gastrodia elata on the cytotoxicity induced by KCl and glutamate［J］. Archives of Pharmacal Research, 2006, 29 (11): 963-968.
［18］王莉，肖宏斌，梁鑫淼．天麻化学成分研究（Ⅲ）［J］．中草药，2009，40 (8)：1186-1189.
［19］YUNCHOI H S, PYO M K. Isolation of 4, 4′dihydroxybenzyl sulfoxide from Gastrodia elata［J］. Archives of pharmacal research，1997, 20 (1): 91-92.
［20］YUNCHOI H S, PYO M K, PARK K M. Isolation of 3O(4′hydroxybenzyl)βsitosterol and 4［4′(4″hydroxybenzyloxy) benzyloxy］benzyl methyl ether from fresh tubers of Gastrodia elata［J］. Archives of pharmacal research, 1998, 21 (3): 357360.
［21］郝小燕，谭宁华，周俊．黔产天麻的化学成分［J］．云南植物研究，2000，22 (1)：81-84.
［22］HAYASHI J, SEKINE T, DEGUCHI S. Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparation ［J］. Phytochemistry, 2002, 59 (5): 513-519.
［23］肖永庆，李丽，游小琳.天麻有效部位化学成分研究 (Ⅰ)［J］．中国中药杂志，2002，27 (1)：35-36.
［24］PYO M K, JIN J L, KOO Y K, et al. Phenolic and furan type compounds isolated from Gastrodia elata and their antiplatelet effects［J］. Archives of Pharmacal Research, 2004, 27 (4): 381-385.
［25］HAN A R, SHIN H J, JEON H R, et al. Two new phenolic compounds from the rhizomes of Gastrodia elata Blume［J］. Helvetica Chimica Acta, 2011, 94 (7): 1310-1314.
［26］LIN J H, LIU Y C, HAU J P, et al. Parishins B and C from rhizomes of Gastrodia elata［J］. Phytochemistry, 1996, 42(2): 549-551.
［27］CHOL J H , LEE D U. A New citryl glycoside from Gastrodia elata and its inhibitory activity on GABA transaminase［J］. Chem Pharm Bull, 2006, 54 (12): 1720-1721.
［28］WANG L, XIAO H, LIANG X, et al. Identification of phenolics and nucleoside derivatives in Gastrodia elata by HPLCUVMS［J］. Journal of separation science, 2007, 30 (10): 14881495.
［29］YANG X D, ZHU J, YANG R, et al. Phenolic constituents from the rhizomes of Gastrodia elata［J］. Natural Product Research, 2007, 21 (2): 180-186.
［30］吴高兵.天麻中的化学成分研究［J］.中国民族民间医药，2013，22 (5)：28.
［31］胡梅清, 夏尔宁, 吴梧桐. 天麻匀多糖的分离纯化和组成分析［J］.铁道医学，1988，16(4): 203-204.
［32］宋振玉．中草药现代研究(第一卷)［M］．北京．北京医科大学中国协和医科大学联合出版社，1995:137.
［33］李志峰，王亚威，王琦，等.天麻的化学成分研究（II）［J］.中草药,2014，45 (14):1976-1979.
［34］ANDERSSON M, BERGENDORFF O, NIELSEN M, et al. Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia［J］. Phytochemistry, 1995, 38 (4): 835-836.
［35］胡忠, 杨増明, 王均.天麻球茎中一种抗真菌蛋白的分离和部分特性［J］.云南植物研究, 1988，10(4): 373-380.
［36］李金玲，赵致，刘红昌，等.基于主成分分析的天麻矿质元素含量研究［J］.中国中药杂志，2015，40(6) ：1123-1128.
［37］杨增明,胡忠.天麻球茎几丁质酶和β1, 3葡聚糖酶的初步研究［J］.云南植物研究，1990，12(4):421-426.
［38］杜伟锋，陈琳，从晓东，等.天麻化学成分及质量控制研究进展［J］.中成药，2011，33(10)：1785-1787.
［39］关萍，石建明，高玉琼.天麻的挥发性成分分析［J］.四川师范大学学报(自然科学版)，2008，31(5):615-618.

[1]	ZHANG Cheng-gang, YANG Chang-gui, XIAO Cheng-hong, FAN Di, GONG An-hui, HUANG Yan, ZHOU Tao. Chemical composition of Radix Dipsaci [J]. Shandong Science, 2022, 35(5): 1-9.
[2]	DONG Hong-jing, YAO Xue, MU Yan, MA Shuang-shuang, GENG Yan-ling, LIU Feng, LIU Wei. Investigation of the pharmacological activity and mechanism of Scutellaria baicalensis Georgi based on the network pharmacology method for explaining its traditional effect [J]. Shandong Science, 2019, 32(5): 54-61.
[3]	CHU Qiao, XI Xing-jun, DONG Gen-lai, ZHAO Xin-ying , WANG wei , WANG Feng-he, ZHANG Wei-bing, LAN Tao . Development of gastrodin certified reference material from the extract of Gastrodia elata Bl. [J]. Shandong Science, 2019, 32(1): 21-28.
[4]	LI Yun, WANG Zhi-wei, LIU Da-hui, ZHOU Hong-lei, WANG Xiao. HPLC determination of multi index components in raw Gastrodia elata Blume [J]. SHANDONG SCIENCE, 2017, 30(2): 7-12.
[5]	CHEN Ling-Xiao, MA Xiu-Li, WANG Xiao, GENG Yan-Ling, GAO Qan-Shan, XIE Hong-Kai, JI Wen-Hua. Absorption and recognition performance of gastrodin molecularly imprinted polymers [J]. J4, 2014, 27(3): 17-22.

Research advances in chemical constituents of Gastrodia elata Blume

PDF (PC)

Like

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 5

Metrics

Comments

Recommended 0