偏最小二乘回归分析法在黄芩抑菌谱-效关系及数学模型研究中的应用

doi:10.3976/j.issn.1002-4026.2020.04.004

Shandong Science ›› 2020, Vol. 33 ›› Issue (4): 18-23.doi: 10.3976/j.issn.1002-4026.2020.04.004

Previous Articles Next Articles

Application of partial least squares regression analysis in the study of the antibacterial spectrum-effect relationship and mathematical model of Scutellariae Radix

DING Xiao-yan,ZU Long-hui,WANG Bian-li

Shandong Key Laboratory of Chinese Medicine Quality Standard Research, Shandong Academy of Chinese Medicine,Jinan 250014,China

Received:2019-11-26 Published:2020-07-27 Online:2020-07-28

Abstract

Abstract: Based on the fingerprint of Scutellariae Radix and its inhibition rate of Staphylococcus aureus, the partial least squares regression method was used to analyze the correlation of the antibacterial spectrum-effect relationship, and a mathematical model was established. Results showed that five components in Scutellariae Radix have a significant effect on the bacteriostasis rate. The established model could predict the efficacy of Scutellariae Radix with a deviation of less than 10%, indicating the desired prediction for the efficacy. The partial least squares regression method and the established mathematical model can provide an effective way to predict the inhibition rate of Staphylococcus aureus for the efficacy of Scutellariae Radix.

Key words: Scutellariae Radix；spectrum-effect relationship, partial least squares regression analysis, mathematical model

CLC Number:

R282.7.1

DING Xiao-yan, ZU Long-hui, WANG Bian-li. Application of partial least squares regression analysis in the study of the antibacterial spectrum-effect relationship and mathematical model of Scutellariae Radix[J].Shandong Science, 2020, 33(4): 18-23.

References 12

1	国家药典委员会. 中华人民共和国药典2015年版一部[M].北京：中国医药科技出版社, 2015: 301302.
2	王晓瑜, 龙汉安. 黄芩及黄酮类成分防治肿瘤作用的研究进展[J]. 华西医学, 2011, 26(2): 297300.
3	思兰兰, 李乐, 陈容娟, 等. 黄芩素和汉黄芩素联合应用对恩替卡韦耐药乙型肝炎病毒的抑制作用及最佳配比观察[J]. 山东医药, 2019, 59(36): 2226.
4	贾富霞, 罗容, 王秀娟. 谱效关系研究方法在中药研究中的应用进展[J]. 北京中医药, 2015, 34(12): 9961000. doi: 10.16025/j.16741307.2015.12.021
5	朱春胜, 聂安政, 王笑, 等. 中药量效关系的研究进展[J]. 中草药, 2019, 50(7): 17081712. doi: 10.7501/j.issn.02532670.2019.07.032
6	张雯霞, 苗雨露, 冯敏, 等. 还贝止咳方不同极性部位止咳作用的谱效关系[J]. 中国实验方剂学杂志, 2019, 25(8): 120127. doi: 10.13422/j.cnki.syfjx.20190516
7	侯恩广, 刘建翔, 刘广敏, 等. 基于主成分分析的金银花药效评价方法研究[J]. 科技创新导报, 2012, 9(4): 217. doi: 10.3969/j.issn.1674098X.2012.04.184
8	张晓莉, 刘宇灵, 樊丽姣, 等. 基于体外抗氧化活性的参芪通脉益智方提取工艺评价及其谱效关系的初步研究[J]. 中国中药杂志, 2016, 41(9): 16351639. doi: 10.4268/cjcmm20160911
9	韩彦琪, 曹勇, 董亚楠, 等. 基于神经网络分析的疏风解毒胶囊抗炎作用谱效关系研究[J]. 中草药, 2019, 50(15): 35263533.
10	邵峰, 谷丽菲, 钟丹丹, 等. 山楂体外降三酰甘油主要活性组分谱效关系研究[J]. 中草药, 2017, 48(2): 339344.
11	相美容, 王孝霞, 孙启慧, 等. 细辛不同极性部位HPLC指纹图谱与其镇痛抗炎活性的谱效关系研究[J]. 辽宁中医杂志, 2016, 43(12): 26032607. doi: 10.13192/j.issn.10001719.2016.12.047
12	王艳辉, 王伽伯, 郝庆秀, 等. 不同产地穿心莲的含量测定、化学指纹图谱及抑菌活性评价[J]. 中国实验方剂学杂志, 2014, 20(9): 7782. doi: 10.13422/j.cnki.syfix.2014090077

Metrics

Comments

Recommended 0

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0), which permits third parties to freely share (i.e., copy and redistribute the material in any medium or format) and adapt (i.e., remix, transform, or build upon the material) the articles published in this journal, provided that appropriate credit is given, a link to the license is provided, and any changes made are indicated. The material may not be used for commercial purposes. For details of the CC BY-NC 4.0 license, please visit: https://creativecommons.org/licenses/by-nc/4.0

[1]	WANG Yuchen, CUI Li, ZHAO Hengqiang, LU Heng, LIU Wei, WANG Xiao. Effect of different slicing methods on the drying characteristics of Salviae Miltiorrhizae Radix Et Rhizoma [J]. Shandong Science, 2023, 36(4): 10-17.
[2]	ZHOU Lue-Lue, WEI Yu-Guang. Soft time window associated model and algorithm for the vehicles routingproblem of logistics distribution center [J]. J4, 2013, 26(5): 104-110.

Application of partial least squares regression analysis in the study of the antibacterial spectrum-effect relationship and mathematical model of Scutellariae Radix

PDF (PC)

Like

Knowledge

Abstract

Cite this article

share this article

References 12

Related Articles 2

Metrics

Comments

Recommended 0