基于斑马鱼模型的琥珀酰缺端胶原蛋白功效研究

doi:10.3976/j.issn.1002-4026.2025092

Abstract

Abstract: This study aimed to systematically evaluate the anti-inflammatory, antioxidant, whitening, and collagen-promoting effects of succinylated telocollagen. In a copper sulfate-induced zebrafish inflammation model, succinylated telocollagen at varying concentrations significantly reduced neutrophil migration (P< 0.001), demonstrating potent anti-inflammatory activity. In a tert-butyl hydroperoxide-induced oxidative stress model, treatment with 25.00 μg/mL of succinylated telocollagen markedly decreased endogenous reactive oxygen species (ROS) levels, as indicated by reduced fluorescence intensity of 2′,7′-dichlorodihydrofluorescein (P< 0.001), confirming its antioxidant capacity. At the same concentration, the protein also exhibited whitening effects by inhibiting melanin production. Furthermore, in human dermal fibroblast cultures, a concentration of 125.00 μg/mL promoted the secretion of type I collagen, suggesting potential skin-repair benefits. These findings collectively indicate that succinylated telocollagen, within the concentration range of 6.25–25.00 μg/mL, possesses integrated anti-inflammatory, antioxidant, whitening, and collagen-enhancing properties, supporting its potential application in functional skincare and biomedical materials.

Key words: , succinoyl atelocollagen, zebrafish model, anti-inflammation, antioxidation, whitening

CLC Number:

R965.1

LIANG Minghui, YE Zikang, ZHOU Ningxin, CUI Jie, SUN Lihe, PENG Xinsheng. Research on the efficacy of succinoyl atelocollagen based on zebrafish models[J].Shandong Science, 0, (): 1-.

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Research on the efficacy of succinoyl atelocollagen based on zebrafish models

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