绵萆薢的化学成分研究

doi:10.3976/j.issn.1002-4026.20240071

山东科学 ›› 2025, Vol. 38 ›› Issue (4): 8-13.doi: 10.3976/j.issn.1002-4026.20240071

绵萆薢的化学成分研究

刘伟^1a^,^1b(), 于金倩^1a^,^1b, 董红敬^1a^,^1b, BOTIROV Erkin Khozhiakbarovich², GUSAKOVA Svetlana Dmitrievna², 王晓^1a^,^1b^,^*()

1.齐鲁工业大学(山东省科学院) a.山东省分析测试中心天然产物分离提取共性技术创新与应用山东省工程研究中心; b.药学院,山东济南 250014
2.乌兹别克斯坦国家科学院植物化学研究所,乌兹别克斯坦塔什干 100170

收稿日期:2024-05-20 出版日期:2025-08-20 发布日期:2025-08-05
通信作者: 王晓 E-mail:liuwei0074@163.com;wangx@sdas.org
作者简介:刘伟(1981—),男,研究员,研究方向为中药资源及质量控制。E-mail: liuwei0074@163.com
基金资助:
科技基础资源调查专项(2018FY100702);山东省泰山学者项目(tstp20221138)

Studies on the chemical constituents of the Dioscorea spongiosa

LIU Wei^1a^,^1b(), YU Jinqian^1a^,^1b, DONG Hongjing^1a^,^1b, BOTIROV Erkin Khozhiakbarovich², GUSAKOVA Svetlana Dmitrievna², WANG Xiao^1a^,^1b^,^*()

1a. Shandong Engineering Research Center for Innovation and Application of General Technology for Separation of Natural Products;b.School of Pharmaceutical Sciences,Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
2. S.Yu. Yunusov Institute of the Chemistry of Plant Substance, Academy of Science of the Republic of Uzbekistan, Tashkent 100170, Uzbekistan

Received:2024-05-20 Online:2025-08-20 Published:2025-08-05
Contact: WANG Xiao E-mail:liuwei0074@163.com;wangx@sdas.org

摘要/Abstract

摘要：

利用大孔树脂、MCI柱色谱、凝胶柱色谱和制备液相等对绵萆薢化学成分进行研究。通过¹H-NMR、¹³C-NMR、ESI-MS等波谱方法鉴定分离得到的化合物结构,从绵萆薢中分离得到10个化合物,分别鉴定为3个芳香族化合物:diosniponol C(1)、3,5-dihydroxy-4,4'-dimethoxybibenzyl(9)、覆盆子酮(10);2个皂苷类化合物:甲基原薯蓣皂苷(2)、原纤细薯蓣皂苷(6);3个二芳基庚烷类化合物:(3R,5R)-3,5-dihydroxy-1,7-bis -(4-hydroxy-3-methoxyphenyl)-heptane 3-O-β-D-glucopyranoside(3)、(3R,5R)-3,5-dihydroxy-1,7-bis(4-hydroxyphenyl)heptane 3-O-β-D-glucopyranoside(4)、(3R,5R)-3,5-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)heptane 3-β-D-glucopyranoside(5);1个生物碱类化合物cyclo(l-Pro-l-Leu)(7);1个甾醇类化合物:β-谷甾醇(8),其中化合物(3~5)、(7)、(9)为首次从绵萆薢药材中分离得到。本研究对绵萆薢70%乙醇提取物化学成分进行系统性分离,丰富了绵萆薢化学成分组成,为绵萆薢的综合开发利用奠定基础。

关键词: 绵萆薢, 化学成分, 结构鉴定

Abstract:

The chemical compositions of Dioscorea spongiosa were investigated using macroporous resin, MCI column chromatography, gel column chromatography and preparative liquid chromatography. The structures of the isolated compounds were identified by ¹H-NMR, ¹³C-NMR, ESI-MS. Ten compounds were isolated from Dioscorea spongiosa, which were identified as three aromatic compounds: diosniponol C (1), 3,5-dihydroxy-4,4'-dimethoxybibenzyl (9), P-hydroxyphenyl butanone (10);two saponin analogues: methyl protodioscin (2), protogracillin (6); three diarylheptanoids: (3R,5R)-3,5-dihydroxy-1,7-bis-(4-hydroxy-3-methoxyphenyl)-heptane 3-O-β-D-glucopyranoside (3), (3R,5R)-3,5-dihydroxy-1,7-bis(4-hydroxyphenyl)heptane 3-O-β-D-glucopyranoside (4), (3R,5R)-3,5-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)heptane 3-β-D-glucopyranoside (5); one alkaloid: cyclo(l-Pro-l-Leu)(7); one sterols: β-sitosterol(8), of which compounds (3~5),(7),(9) were isolated from Dioscorea spongiosa for the first time. In this study, the chemical constituents of 70% ethanol extract of Dioscorea spongiosa were systematically isolated, which enriched the chemical composition and laid the foundation for the comprehensive development of Dioscorea spongiosa.

Key words: Dioscorea spongiosa, chemical constituents, structural identification

中图分类号:

刘伟, 于金倩, 董红敬, BOTIROV Erkin Khozhiakbarovich, GUSAKOVA Svetlana Dmitrievna, 王晓. 绵萆薢的化学成分研究[J]. 山东科学, 2025, 38(4): 8-13.

LIU Wei, YU Jinqian, DONG Hongjing, BOTIROV Erkin Khozhiakbarovich, GUSAKOVA Svetlana Dmitrievna, WANG Xiao. Studies on the chemical constituents of the Dioscorea spongiosa[J]. Shandong Science, 2025, 38(4): 8-13.

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绵萆薢的化学成分研究

Studies on the chemical constituents of the Dioscorea spongiosa

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