浙贝母花化学成分研究

doi:10.3976/j.issn.1002-4026.2020.06.004

Shandong Science ›› 2020, Vol. 33 ›› Issue (6): 22-26.doi: 10.3976/j.issn.1002-4026.2020.06.004

• Traditional Chinese medicine and natural active products • Previous Articles Next Articles

Chemical constituents of flowers of Fritillariae Thunbergii Miq.

WU Guo-zhen¹，CUI Ming-chao^2,3，YAO Xue¹，PAN Shao-bin¹，ZHAO Hong-wei¹，LIU Wei⁴，LI Jia^1*

1.College of Pharmacy, Shandong University of Traditional Chinese Medicine,Jinan 250355,China；2.College of Traditional,Chinese Medicine，Zhejiang Pharmaceutical College，Ningbo 315100，China；3.Colloge of Pharmacy，Nanjing University of Traditional Chinese Medicine，Nanjing 210023，China；4.Shandong Analysis and Test Center， Qilu University of Technology (Shandong Academy of Sciences)，Jinan 250014，China

Received:2020-03-09 Online:2020-12-09 Published:2020-12-09

Abstract

Abstract: Chemical constituents of the ethyl acetate part from 95% ethanol extract of flowers of Fritillariae Thunbergii Miq.were studied herein. Positive silica gel column chromatography, reverse C18 medium pressure column chromatography, and semi-preparative high performance liquid chromatography were used for the separation and purification. The structures of the obtained compounds were identified using NMR and MS. From the ethyl acetate extract of the flowers of Fritillariae Thunbergii Miq., eight compounds were isolated and identified, which included n-nonacosane(1), linoleic acid(2), palmitic acid(3), trans-ferulic acid(4), trans-p-hydroxy cinnamic acid(5), caffeic acid(6), esculetin(7), and Z-p-hydroxyl cinnamic acid (8). To the best of our knowledge, compound 1~8 are all isolated from this plant for the first time.

Key words: flowers of Fritillariae Thunbergii Miq., extraction and isolation, chemical constituents

CLC Number:

R284.2

WU Guo-zhen, CUI Ming-chao, YAO Xue, PAN Shao-bin, ZHAO Hong-wei, LIU Wei, LI Jia. Chemical constituents of flowers of Fritillariae Thunbergii Miq.[J].Shandong Science, 2020, 33(6): 22-26.

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Chemical constituents of flowers of Fritillariae Thunbergii Miq.

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