肌小节组装研究进展

doi:10.3976/j.issn.1002-4026.2017.02.005

Abstract

Abstract:

As the basic contractile unit of striated muscles, sarcomere has a highly ordered structure, which was assembled by Actin, Myosin, and a variety of related proteins. During the assembling process, the correcting assembly of Z belt, M belt, and a series of associated proteins is essential for maintaining movement of muscles, so the study on the mechanism of folding and assembling of sarcomere composition protein is very important for understanding the causes of muscle disease and carrying out targeted therapy. In this paper, the research progress of sarcomere primary components and sarcomere assembling process was reviewed. It was considered that the present studies on sarcomere skeleton assembly, the function of the sarcomere contractile complex, and the relationship between the chaperones and muscle diseases were not deep enough. Therefore, in the future, more studies should be developed on the relationship between Myosin binding protein, Titin, molecular chaperones, and diseases, to find new ideas and solutions to the treatment of muscle related diseases.

Key words: sarcomere, assembling, molecular chaperones, assembling, molecular chaperones, muscle protein, sarcomere, muscle protein

CLC Number:

Q445

HOU Cai-ping, HAN Li-wen, HOU Hai-rong, WANG Xi-min, ZHANG Shan-shan,ZHANG Xuan-ming, WANG Xue, LI Xiao-bin, TIAN Qing-ping, HE Qiu-xia, LIU Ke-chun. The research progress of sarcomere assembly[J].SHANDONG SCIENCE, 2017, 30(2): 25-36.

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The research progress of sarcomere assembly

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