高速逆流色谱,杭白菊,小白菊内酯," /> 高速逆流色谱,杭白菊,小白菊内酯,"/> parthenolide,high-speed counter-current chromatography,continuous multiple preparation,Chrysanthemum morifolium,"/> <div style="line-height: 150%;">Continuous separation and preparation of parthenolide from Chrysanthemum morifolium with high-speed counter-current chromatography</div>  

SHANDONG SCIENCE ›› 2016, Vol. 29 ›› Issue (3): 18-22.doi: 10.3976/j.issn.1002-4026.2016.03.004

• Traditional Chinese medicine and natural active products • Previous Articles     Next Articles

Continuous separation and preparation of parthenolide from Chrysanthemum morifolium with high-speed counter-current chromatography
 

SUN Zhao-lin1,2,YAN Hui-jiao1,GONG Cheng-yu3,SUN Chang-lei1,2,WANG Dai-jie1,LI Jia2,WANG Zhi-wei1,WANG Xiao1,2   

  1. 1. Shandong Provincial Key Laboratory ofTCM Quality Control Technology, Shandong Analysis and Test Center, Jinan 250014, China; 2. School of Pharmacy,Shandong University of Traditional Chinese Medicine, Jinan 250355, China; 3.Yantai Entry Exit Inspection and Quarantine Bureau, Yantai264000, China
  • Received:2015-12-10 Published:2016-06-20 Online:2016-06-20

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Abstract:

We separated and prepared parthenolide from Chrysanthemum morifolium with continuous multiple preparation and high-speed counter-current chromatography ( HSCCC) . We acquired parthenolide of 5.0, 5.2 and 5.5 mg from Chrysanthemum morifolium extract of 330, 350 and 370 mg. Their purities were respectively 93.
1%, 92. 6%, and 92. 9%. Experimental conditions were HSCCC, solvent system of n-hexane-ethyl acetate-methanol-water ( 5∶5∶6∶4, V/ V) , upper stationary phase and lower mobile phase, rotation speed of 800.0 r/ min, flow rate of 2.0 mL/ min and detection wavelength of 254 nm. It shows that continuous preparation HSCCC can efficiently separate and purify parthenolide from Chrysanthemum morifolium.

 

Key words: parthenolide')">parthenolide, high-speed counter-current chromatography')">high-speed counter-current chromatography, continuous multiple preparation, Chrysanthemum morifolium

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  • Cite this article

    SUN Zhao-lin,YAN Hui-jiao,GONG Cheng-yu,SUN Chang-lei,WANG Dai-jie,LI Jia,WANG Zhi-wei,WANG Xiao.

    Continuous separation and preparation of parthenolide from Chrysanthemum morifolium with high-speed counter-current chromatography
     [J].SHANDONG SCIENCE, 2016, 29(3): 18-22.

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