4-二甲胺基丁醛二乙基缩醛的合成

Abstract

Abstract:

4-Dimethylaminobutyraldehyde diethyl acetal is a key intermediate for the preparation of anti-migraine drugs. Its synthesis technique significantly affects the production cost of anti-migraine drugs. We catalyzed the reaction of 1-bromo-3-chloro propane and dimethylamine solution with PEG as a phase transfer catalyst, and obtained 3-dimethylamino-1-chloro propane. 3-dimethylamino-1-chloro propane reacted with magnesium and Grinard reagent was acquired. We eventually obtained our target compound by the reaction of Grinard reagent and triethyl orthoformate. The total recovery rate of our target compound was 70.11%. The advantages of this method are simple operation, low environment pollution, high recovery rate and easy implementation.

Key words: 4-dimethylaminobutyraldehyde diethyl acetal, synthesis, Sumartriptan

CLC Number:

FENG Run-Liang, CHEN Xiu-Yi, SONG Zhi-Mei, YUE Dong-Ling. 4-Dimethylaminobutyraldehyde diethyl acetal[J].J4, 2011, 24(5): 1-4.

References

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4-Dimethylaminobutyraldehyde diethyl acetal

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