生物力学作用对骨髓间充质干细胞增殖和成骨分化影响研究进展

doi:10.3976/j.issn.1002-4026.2021.02.009

Abstract

Abstract: The biomechanical environment of bone marrow mesenchymal stem cells (BMSCs) in vivo is relatively complex. To explore the relationship between biomechanics and the proliferation and osteogenic differentiation of BMSC, This review summarizes the current research status and latest progress of the effects of biomechanical microenvironment on the proliferation and differentiation of bone marrow mesenchymal sterm cells in recent years.Results showed that mechanical tension stress and fluid shear stress on BMSCs generated most of the stimuli to direct cell differentiation and that larger compression force and static water pressure on BMSCs generated most of the stimuli to direct cells toward cartilage differentiation and a minority of cells toward osteogenic differentiation. Cell differentiation in each direction occurred under its optimal conditions. Here we reviewed the effects of biomechanics on proliferation and osteogenic differentiation of BMSC, which may provide insights and references for research on bone tissue engineering, regenerative medicine, and clinical applications of BMSCs.

Key words: bone marrow mesenchymal stem cells, biomechanics, proliferation, osteogenic differentiation

CLC Number:

CAO Sheng-nan, SHI Bin, SUN Guo-dong, WANG Cong-an, WANG Dan-dan. Research progress on the effect of biomechanics on proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells[J].Shandong Science, 2021, 34(2): 65-74.

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Research progress on the effect of biomechanics on proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells

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