头孢地尼中杂质来源分析与合成

doi:10.3976/j.issn.1002-4026.2021.02.006

Abstract

Abstract: To improve the quality control of Cefdinir API and establish its quality criteria, the preparation method for Cefdinir was analyzed and five related impurities (Thiazolylacetyl glycine oxime, impurity O, impurity D, impurity G, and impurity S) were synthesized and characterized by 1H NMR and Ms. The purities of related substances obtained by HPLC detection were over 99%，and can be used as impurity reference substances for the quality control of Cefdinir, which provides a basis for the industrial development and quality control of Cefdinir.

Key words: Cefdinir, Cephalosporin, impurity, synthesis

CLC Number:

TQ460.6

WANG Jing, WU Dan, LIU Long. Analysis and synthesis of impurity source in Cefdinir[J].Shandong Science, 2021, 34(2): 42-47.

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Analysis and synthesis of impurity source in Cefdinir

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