头孢硫脒热分解动力学研究

doi:10.3976/j.issn.1002-4026.2019.06.006

Abstract

Abstract: The kinetics of the thermal decomposition of cefathiamidine was investigated by thermal gravity-differential thermal gravity (TG-DTG). The thermal decomposition of cefathiamidine was accomplished in one step, and the initial decomposition temperature ranged from 430 K to 450 K. The activation energy of the thermal decomposition process of cefathiamidine was obtained using the Flynn-Wall-Ozawa method, Kissinger-Akahira-Sunose method, and Starink method. The activation energy decreased with an increase in the thermal decomposition conversion rate. Further, the three factors of the thermal decomposition kinetics of the ceftiamidine crystals were obtained using the Málek method. The calculated E_αwas 109 kJ/mol, lnA was 30.60 s^-1, and most probable kinetic model was SB(0.241 7, 0.658 9). The calculated theoretical shelf time of cefathiamidine was three years below 273.15 K.

Key words: cefathiamidine, thermal decomposition, kinetics of thermal analysis, TG-DTG, shelf time

CLC Number:

R912

YU Shuai, CHENG Yan, XUE Fu-min. Kinetics of the thermal decomposition of cefathiamidine[J].Shandong Science, 2019, 32(6): 34-42.

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Kinetics of the thermal decomposition of cefathiamidine

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