细辛挥发油环糊精包合物制备工艺的正交试验研究

doi:10.3976/j.issn.1002-4026.2019.02.003

Abstract

Abstract: In order to optimize the preparation technology of inclusion of volatile oil from Asarum by β-cyclodextrin, the inclusion rate of methyleugenol, yield and drug loading rate in volatile oil from Asarum were taken as indicators, the technological conditions of inclusion of β-cyclodextrin were optimized by orthogonal tests, and the content of methyleugenol was determined by HPLC. The results showed the optimum inclusion process was that: volatile oil volume(mL):β-CD quality(g)was 1:6, inclusion temperature was 60 ℃ and inclusion time was 1 h.The inclusion of methyleugenol rate, drug loading rate and inclusion complex yield were 74.64%, 8.72% and 77.23% respectively. The optimized inclusion process was simple, stable and suitable for industrial production.

Key words: volatile oil from Asarum, methyleugenol, β-CD, inclusion process, orthogonal tests, HLPC

CLC Number:

R283.3

GUO Cheng-cheng, GAO Shuang, WANG Yu-zhen, XIE Hui-chao, MA Xue-mei, RONG Rong, YANG Yong, LI Ling-jun. Study on the preparation of cyclodextrin inclusion complex of volatile oil from Asarum by orthogonal tests[J].Shandong Science, 2019, 32(2): 15-21.

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	</p>
	<p>
［5］	黄顺旺.细辛的药理毒理和临床应用[J].安徽医药,2003,7(6)：477- 479. DOI： 10.3969/j.issn.1009-6469.2003.06.049.
	</p>
	<p>
［6］	陈蓓，胡苏莹，李昆伟，等．三种细辛挥发性成分的比较研究［J］．中药材，2010,33(12): 18861893．
［7］	杨春澍，张家俊，潘炯光，等.中国细辛属植物挥发油的气相色谱质谱分析(第四报)[J].中药通报,1986,11(7):39-43.
［8］	王娟，马春梅，袁绍莉，等.星点设计－效应面法优化川芎和细辛挥发油的包合工艺研究[J].甘肃中医药大学学报，2017,34(2):53-57.
	</p>
	<p>
［9］	穆启运,阮新民. β环糊精包合川芎和细辛挥发油的正交试验研究[J]. 广州中医药大学学报,2009,26(5):471-474. DOI：10.3969/j.issn.1007-3213.2009.05.012.<br />
［10］	马容,狄留庆,毕肖林,等. 细辛、辛夷挥发油β-环糊精和HP-β-环糊精包合物的制备及其对透皮吸收的影响[J]. 中国中医药信息杂志,2008，15(6):52-53. DOI： 10.3969/j.issn.1005-5304.2008.06.023.<br />
［11］	朱晗,周晶,董盼盼,等.正交试验法优选细辛挥发油β-环糊精包合工艺[J].数理医药学杂志, 2016, 29(12): 1805-1808. DOI：10.3969/j.issn.1004-4337.2016.12.031.<br />
［12］	张生潭，张帆，汪铁山，等．正交试验优选春砂仁挥发油羟丙基-β-环糊精包合工艺［J］.中国药房，2011，22(3):225-228．<br />
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	</p>

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Study on the preparation of cyclodextrin inclusion complex of volatile oil from Asarum by orthogonal tests

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