呼吸道合胞病毒及其感染相关TLRs的研究进展

doi:10.3976/j.issn.1002-4026.2020.01.007

摘要/Abstract

摘要： 呼吸道合胞病毒（respiratory syncytial virus ,RSV）是婴幼儿呼吸道感染的主要原因，Toll样受体（Toll-like receptors ,TLRs）是参与固有免疫的模式识别受体，在识别与清除RSV过程中发挥重要作用。当前对此研究尚不明确，限制了抗病毒药物和疫苗研发的进程。本研究就近年与RSV相关TLRs免疫过程研究展开综述，提出当前研究在方法和方向上存在的不足，为下一步开展抗RSV新药及其机制研究提供思路和方法。

关键词: 呼吸道合胞病毒, Toll样受体, 机制, 抗病毒

Abstract: Respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in infants. Toll-like receptors, one of the pattern recognition receptors involved in innate immunity, play an important role in the identification and eradication of RSVs. However, this is not adequately examined, which has limited the development of antiviral drugs and vaccines. In this study, we reviewed the studies on the immunologic process of RSV-related Toll-like receptors in recent years and described the shortcomings of the methods and tendencies of the current studies. This is intended to provide ideas and methods for the further studies on new anti-RSV drugs and their mechanisms.

Key words: respiratory syncytial virus, toll-like receptors, mechanism, anti-virus

中图分类号:

R289

杜海涛, 孙铁锋, 王平, 安丰田, 胡亚楠, 李娜. 呼吸道合胞病毒及其感染相关TLRs的研究进展[J]. 山东科学, 2020, 33(1): 42-50.

DU Hai-tao, SUN Tie-feng, WANG Ping, AN Feng-tian, HU Ya-nan, LI Na. Advances in respiratory syncytial virus and its infection-related Toll-like receptors[J]. Shandong Science, 2020, 33(1): 42-50.

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