黄芩及其有效成分治疗溃疡性结肠炎机制研究进展

doi:10.3976/j.issn.1002-4026.20240017

摘要/Abstract

摘要：

溃疡性结肠炎是一种炎症性肠病,以持续黏膜炎症为特征,黄芩作为临床常用中药之一,具有清热燥湿、泻火解毒、止血安胎的功效,其组方常用于治疗湿热型溃疡性结肠炎,如黄芩汤、芍药汤、葛根芩连汤等。研究表明,黄芩及其有效成分在保护肠黏膜、抗炎、免疫调节中起到重要作用。本文对近年来黄芩及其有效成分(黄芩苷、黄芩素、汉黄芩苷、汉黄芩素、黄芩多糖等)通过保护和修复肠道黏膜屏障、抗炎、调节免疫、抗氧化应激、调节肠道菌群等来治疗溃疡性结肠炎的作用机制进行了综述,以期为溃疡性结肠炎针对性的临床治疗和创新药研发提供参考。

关键词: 溃疡性结肠炎, 黄芩, 有效成分, 作用机制

Abstract:

Ulcerative colitis (UC) is an inflammatory bowel disease characterized by persistent mucosal inflammation.Scutellaria baicalensis (also known as Huangqin), as a common traditional Chinese medicines used in clinical practice, is known for its efficacy at clearing internal heat,eliminating dampness, purging fire,eliminating toxins, stopping bleeding, and calming fetal activity. Its formulations, including Huangqin Decoction, Peony Decoction, and Pueraria, Scutellaria, and Coptis Decoction, are often used to treat damp-heat UC. Studies have shown that S. baicalensis and its active ingredients play an important role in protecting the intestinal mucosa, and have anti-inflammatory and immunomodulatory effects. This study reviews the mechanism of action of S. baicalensisand its active ingredients (baicalin,baicalein,oroxindin, wogonin, Scutellaria baicalensis polysaccharide, etc.) in the treatment of UC in recent years, including the protection and repair of the intestinal mucosal barrier, the active ingredients anti-inflammatory and immunomodulatory properties, effects against antioxidative stress, and regulation of intestinal flora, to provide a reference for targeted clinical treatment of UC and drug development.

Key words: ulcerative colitis, Scutellaria baicalensis, active ingredient, mechanism of action

中图分类号:

R285

罗雅琴, 黄伟. 黄芩及其有效成分治疗溃疡性结肠炎机制研究进展[J]. 山东科学, 2024, 37(2): 20-28.

LUO Yaqin, HUANG Wei. Progress in the research on the mechanism of action of Scutellaria baicalensis and its active ingredients in treating ulcerative colitis[J]. Shandong Science, 2024, 37(2): 20-28.

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