天然多酚类成分缓解高尿酸血症及其机制研究进展

doi:10.3976/j.issn.1002-4026.20240028

摘要/Abstract

摘要：

高尿酸血症(hyperuricemia, HUA)是一种机体中嘌呤类物质代谢紊乱导致血清中尿酸水平升高的一种代谢性疾病,严重者可导致痛风。HUA的发病机制主要包括酶活失调、尿酸转运体表达失衡、糖代谢及脂代谢紊乱、肠道稳态失衡等。许多研究报道了天然多酚对高尿酸血症和痛风具有良好的缓解作用。本文对HUA的发病机制和多酚类成分的降尿酸作用及其机制进行了总结与归纳,以期为降尿酸药物的研究与开发提供理论依据。

关键词: 多酚类成分, 高尿酸血症, 作用机制, 研究进展

Abstract:

Hyperuricemia (HUA) is a metabolic disorder caused by the physiologic disorders in purine metabolism, resulting in increased serum uric acid levels, which can lead to gout in severe cases. HUA pathogenesis primarily involves enzyme dysfunction, urate transporter expression dysregulation, glucose and lipid metabolism disorders, and intestinal homeostasis disruption. Numerous studies have reported the effectiveness of natural polyphenols in alleviating hyperuricemia and gout. This article summarizes HUA pathogenesis and the mechanisms of action of polyphenolic compounds in reducing uric acid, to provide a theoretical basis for the research and development of uric acid-lowering drugs.

Key words: polyphenols, hyperuricemia, mechanism of action, research progress

中图分类号:

R285

刘双, 董红敬, 陈盼盼, 王晓. 天然多酚类成分缓解高尿酸血症及其机制研究进展[J]. 山东科学, 2024, 37(2): 12-19.

LIU Shuang, DONG Hongjing, CHEN Panpan, WANG Xiao. Research progress on the mechanisms by which natural phenolic compounds alleviate hyperuricemia[J]. Shandong Science, 2024, 37(2): 12-19.

图/表 2

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