山东科学 ›› 2024, Vol. 37 ›› Issue (2): 29-35.doi: 10.3976/j.issn.1002-4026.20240014

• 药理与毒理 • 上一篇    下一篇

网络药理学和斑马鱼模型在中药药效物质及作用机制研究中的应用进展

刘可春(), 王勇澄, 臧晓涵, 夏青, 张云, 张姗姗, 孙晨   

  1. 齐鲁工业大学(山东省科学院) 山东省科学院生物研究所 山东省人类疾病斑马鱼模型与药物筛选工程技术研究中心,山东 济南 250014
  • 收稿日期:2024-01-20 出版日期:2024-04-20 发布日期:2024-04-09
  • 作者简介:刘可春(1964—),男,博士,研究员,研究方向为药物筛选、药物早期成药性评价及新产品研发。E-mail:liukechun2000@163.com,Tel:15020009568
  • 基金资助:
    山东省重点研发计划(重大科技创新工程)(2021CXGC10507);山东省重点研发计划(重大科技创新工程)(2022CXGC020515);山东省中央引导地方科技发展资金项目(YDZX2022164)

Advancements in network pharmacology and zebrafish modeling for studying traditional Chinese medicine’s effective substances and mechanisms of action

LIU Kechun(), WANG Yongcheng, ZANG Xiaohan, XIA Qing, ZHANG Yun, ZHANG Shanshan, SUN Chen   

  1. Engineering Research Center of Zebrafish Model for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China
  • Received:2024-01-20 Online:2024-04-20 Published:2024-04-09

摘要:

网络药理学高度契合中药多成分、多靶点的整体观和系统论思想,在中药现代化过程中迅速发展。实验验证是网络药理学的关键研究内容之一。斑马鱼模型具有完整的药物代谢系统、复杂的体内环境和靶点、通路调控机制,且利用该模型开展实验具有用药量少、高通量、周期短等优势。近年来,网络药理学预测结合斑马鱼模型实验验证的研究模式,在阐明中药药效物质及作用机制方面得到广泛应用。本文对网络药理学和斑马鱼模型综合应用的进展及发展趋势进行综述,以期为该方法在阐明中药功效现代科学内涵中的应用提供参考。

关键词: 网络药理学, 斑马鱼, 中药, 药效物质, 机制, 质量标志物

Abstract:

Network pharmacology, which is highly consistent with the holistic and systematic perspectives of traditional Chinese medicine (TCM) with its multiple components and targets, has rapidly developed in the modernization of TCM. Experimental verification is one of the key contents of network pharmacology research. The zebrafish model has a complete system of drug metabolism, as well as a complex in vivo environment and target and pathway regulation mechanisms. Experiments that utilize this model have the advantages of low drug dosage, high throughput, and short cycle time. In recent years, the research mode that combines network pharmacology prediction with experimental validation using the zebrafish model has been widely applied to elucidate the effective substances and mechanisms of action of TCM. This study reviews the progress and development trends in the comprehensive application of network pharmacology and zebrafish modeling, aiming to provide a reference for their application in elucidating the modern scientific implications of the efficacy of TCM.

Key words: network pharmacology, zebrafish, traditional Chinese medicine, effective substances, mechanism, quality markers

中图分类号: 

  • R285.5

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