基于网络药理学研究黄芪-半枝莲药对治疗肺癌机制

doi:10.3976/j.issn.1002-4026.2020.06.006

Abstract

Abstract: We aimed to determine the mechanism of Astragali Radix-Scutellariae Ｂarbatae Herba (AR-SBH) medicine in treating lung cancer. The active ingredient and target protein of the drug pair AR-SBH and lung cancer-related disease targets were searched through a database. The drug-compound-target and compound-target-disease networks were constructed. A protein-protein interaction(PPI) network of key targets was established, followed by analysis using R software for gene ontology(GO）and Kyoto Encyclopedia of Genes and Genomes(KEGG） key target enrichment. Sixteen effective active ingredients of the drug pair AR-SBH were obtained, which acted on 111 lung cancer-related targets. Key targets included TP53, AKT1, MAPK, TNF, VEGFA, and IL-6. GO enrichment analysis mainly involves RNA transcription, inflammation, extracellular, and nuclear. KEGG signaling pathway mainly includes TLR, NLR, HIF-1, FoxO, PI3K-Akt, and other pathways. AR-SBH plays a role in treating lung cancer by inhibiting inflammation, signal transduction, angiogenesis, and other processes. The results predict the molecular mechanism of AR-SBH in lung cancer treatment and lay a foundation for further in-depth study on the pharmacological effects of the drug pair AR-SBH.

Key words: Astragali Radix-Scutellariae Barbatae Herba; lung cancer, network pharmacology, tumor necrosis factor

CLC Number:

R285

HOU Yue, LI Qiang, WANG Dai-jie, CUI Li, ZHENG Xin. Mechanisms of the drug pair Astragali Radix-Scutellariae Barbatae Herba in treating lung cancer based on network pharmacology[J].Shandong Science, 2020, 33(6): 34-43.

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Mechanisms of the drug pair Astragali Radix-Scutellariae Barbatae Herba in treating lung cancer based on network pharmacology

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