Abstract:

        In pharmaceutical research,the supramolecular inclusion hosts include crown ether, cyclodextrin, calixarene and cucurbituril. They all have cavity structure and can form supermolecules with other ions and neutral molecules by the noncovalent bonds,which can improve medical stability. This paper surveys application advances of these supramolecular hosts in the pharmaceutical development.It also presents the application prospect of supramolecular inclusion technique in new medicine development.

Key words: supramolecular inclusion technique, inclusion effect, pharmaceutical development, inclusion compound