网络药理学在中药复杂作用模式研究中的应用进展

doi:10.3976/j.issn.1002-4026.2021.06.004

摘要/Abstract

摘要：

中药多层次、多系统的复杂作用模式的表征一直是中药现代研究的一个关键问题。网络药理学借助计算机技术、系统生物学、多向药理学等多学科的交叉融合,形成了以网络靶标为核心的技术体系,实现了成分-靶标-疾病的分子网络构建,在中药现代研究中显示了巨大的潜力。对近年来网络药理学在网络构建及分析技术、中药复杂作用模式研究进展、未来发展趋势等方面进行了综述,以期为传统中药科学内涵的深入阐释提供新的思路。

关键词: 网络药理学, 中药, 作用模式, 网络靶标, 应用进展

Abstract:

The complex mechanisms of action of traditional Chinese medicine (TCM), which are characterized by multilevels and multisystems, have always been a crucial scientific problem in modern research. With the integration of computer technology, systems biology, multidirectional pharmacology, and other disciplines, network pharmacology has formed a core technical system based on network targets, which has established component-target-disease molecular networks and shown great application potential in the modern research of TCM. We reviewed the network construction and analysis technology of network pharmacology, recent research progress in elucidating TCM's pharmacological mechanism of action, and the potential for further development of network pharmacology to provide useful reference for conducting in-depth interpretation of the scientific connotation of TCM.

Key words: network pharmacology, traditional Chinese medicine, mechanism of action, network target, research progress

中图分类号:

R285

韩利文, 陈善军, 董榕, 张友刚, 王晓静. 网络药理学在中药复杂作用模式研究中的应用进展[J]. 山东科学, 2021, 34(6): 22-31.

HAN Li-wen, CHEN Shan-jun, DONG Rong, ZHANG You-gang, WANG Xiao-jing. Progress of network pharmacology applications in studying the complex mechanisms of action of traditional Chinese medicine[J]. Shandong Science, 2021, 34(6): 22-31.

图/表 1

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