模式生物斑马鱼在化妆品功效评价中的应用进展及发展趋势分析

doi:10.3976/j.issn.1002-4026.20240016

摘要/Abstract

摘要：

斑马鱼模型在药物筛选、药理和毒理等研究领域已得到广泛应用。近年来,随着《化妆品功效宣称评价规范》等文件的实施,化妆品功效宣称进入强监管时代,对功效评价模型和方法的科学性提出了更高的要求。斑马鱼皮肤结构与人类高度相似,胚胎透明,易观察,且斑马鱼功效评价实验具有样品用量少、周期短、高通量的优势,目前已成为化妆品功效评价领域的研究热点。本文基于文献计量学方法,统计了近十年斑马鱼用于化妆品功效评价的相关文献,综述了斑马鱼在化妆品功效评价中的应用进展,并分析了其发展动态和趋势,为促进斑马鱼模型在化妆品领域中的应用提供参考。

关键词: 斑马鱼, 化妆品, 功效评价

Abstract:

Zebrafish models have been widely used in various fields such as drug screening, pharmacology, and toxicology research. In recent years, with the implementation of regulations such as the standard for the Evaluation of Cosmetic Efficacy Claims, cosmetic efficacy claims have entered into an era of strict supervision, which has led to higher standards for the scientific nature of the efficacy evaluation models and methods. The skin structure of zebrafish is highly similar to that of humans, with zebrafish also having transparent embryos that are easy to observe. Moreover, efficacy evaluation experiments using zebrafish offer advantages such as minimal sample dosage, shortened experimental cycles, and high-throughput capacity. Consequently, zebrafish have become a popular research topic in the field of cosmetic efficacy evaluation. Based on bibliometric methods, this study analyzes the relevant literature on the use of zebrafish to evaluate cosmetic efficacy over the past decade. The study provides an overview of the progress of the application of zebrafish in cosmetic efficacy evaluation, and examines the development dynamics and trends through comprehensive analysis. This is so as to provide a reference for the application of zebrafish models in the cosmetics industry.

Key words: zebrafish, cosmetics, efficacy evaluation

中图分类号:

夏青, 臧晓涵, 王勇澄, 张云, 李培海, 张轩铭, 刘可春. 模式生物斑马鱼在化妆品功效评价中的应用进展及发展趋势分析[J]. 山东科学, 2024, 37(2): 36-46.

XIA Qing, ZANG Xiaohan, WANG Yongcheng, ZHANG Yun, LI Peihai, ZHANG Xuanming, LIU Kechun. Progress and development trends in the use of zebrafish as a model organism for evaluating cosmetic efficacy[J]. Shandong Science, 2024, 37(2): 36-46.

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位置	结构	功能	对应人体皮肤结构
表皮层	保护膜	保护,抗菌	角化上皮
	浅表层	稳定,气体交换,防震动	颗粒层
	中间层	棒状细胞,离子细胞,感觉细胞,黏液细胞,未分化上皮细胞	棘层
	基底层	通过半桥粒附着在真皮上	基底层
	透明层	含有层黏连蛋白和整合素	透明层
	致密层	含有胶原蛋白	致密层
	半桥粒	连接基底层细胞与下方基底膜	半桥粒
	桥粒	连接相邻上皮细胞	桥粒
	侧线	运动和震动的感觉器官	内耳毛细胞(位于耳蜗内)
真皮层	黑素细胞	色素沉着,抗紫外线辐射	黑素细胞
真皮层	鳞	保护,钙源	毛发
皮下组织	脂肪细胞	隔热,储存热量,有助皮下创伤愈合	脂肪细胞