基于响应面设计的头孢他啶母液冷冻浓缩工艺优化

doi:10.3976/j.issn.1002-4026.2021.05.015

山东科学 ›› 2021, Vol. 34 ›› Issue (5): 121-129.doi: 10.3976/j.issn.1002-4026.2021.05.015

基于响应面设计的头孢他啶母液冷冻浓缩工艺优化

贾全，胡利敏，任峰，张建丽，田洪年*，刘树斌*

华北制药河北华民药业有限责任公司，河北石家庄052165

收稿日期:2020-11-18 出版日期:2021-10-14 发布日期:2021-10-19
通信作者: 田洪年，男，高级工程师，研究方向为头孢类抗生素合成及结晶技术。E-mail: hongnian@126.com；刘树斌，男，助理工程师，研究方向为头孢类抗生素合成及结晶技术。E-mail: 15832113276@163.com
作者简介:贾全（1981—），男，高级工程师，研究方向为头孢类抗生素合成及结晶技术。E-mail: hcho1101@126.com

Optimization of the freeze concentration process of ceftazidime mother liquor based on the response surface method

JIA Quan，HU Li-min，REN Feng，ZHANG Jian-li，TIAN Hong-nian*，LIU Shu-bin*

NCPC Hebei Huamin Pharmaceutical Co., Ltd., Shijiazhuang 052165，China

Received:2020-11-18 Online:2021-10-14 Published:2021-10-19

摘要/Abstract

摘要： 以头孢他啶母液为原料，采用悬浮结晶冷冻浓缩技术回收头孢他啶母液中的有效成分。在单因素试验数据基础上，以头孢他啶回收率为评价指标，应用Box-Behnken响应面设计对冷冻温度、冷冻时间以及搅拌速率3个提取条件进行3因素3水平回归分析，优化最佳提取条件。得出头孢他啶最佳回收工艺条件为：冷冻温度－7 ℃，冷冻时间3 h，搅拌速率20 r/min。验证实验结果表明，此条件下头孢他啶回收率达到93.15%。结合生产实际情况优选的悬浮结晶冷冻浓缩工艺稳定，为头孢他啶的后续研究提供了一定的参考。

关键词: 头孢他啶, 冷冻浓缩, 响应面设计, 悬浮结晶冷冻浓缩

Abstract: Using ceftazidime mother liquor as the raw material, we recovered its effective components using suspension freeze concentration technology. Based on single factor test data, taking the recovery rate of ceftazidime as the evaluation index, we used the Box-Behnken response surface method to analyze the three extraction conditions of freezing temperature, freezing time, and stirring rate in three levels respectively to optimize the extraction conditions. The optimum recovery conditions of ceftazidime were as follows: freezing temperature -7 ℃, freezing time 3 h, stirring rate 20 r/min. Results show that the recovery of ceftazidime under these conditions was 93.15%.Combined with the actual production situation, the optimized suspension freeze concentration process is stable and can shed light on the follow-up study of ceftazidime.

Key words: ceftazidime, freeze concentration, response surface method, suspension crystallization freeze concentration

中图分类号:

R978.1

贾全, 胡利敏, 任峰, 张建丽, 田洪年, 刘树斌. 基于响应面设计的头孢他啶母液冷冻浓缩工艺优化[J]. 山东科学, 2021, 34(5): 121-129.

JIA Quan, HU Li-min, REN Feng, ZHANG Jian-li, TIAN Hong-nian, LIU Shu-bin. Optimization of the freeze concentration process of ceftazidime mother liquor based on the response surface method[J]. Shandong Science, 2021, 34(5): 121-129.

参考文献 13

1	赵锦锦, 张菁. 头孢他啶-阿维巴坦药品说明书[J]. 国外医药(抗生素分册), 2019, 40(2):115-127. doi: 10.13461/j.cnki.wna.005206
2	王琰, 张斗胜, 田冶, 等. 一种头孢他啶晶体制备方法及晶体结构测定[J]. 中国新药杂志, 2020, 29(15): 1764-1769.
3	徐成苗, 余杰, 沈江南, 等. 纳滤回收头孢拉定母液的实验研究[J]. 过滤与分离, 2013, 23(2): 13-17. doi: 10.3969/j.issn.1005-8265.2013.02.004
4	李丽娟, 刘崧, 石磊, 等. 树脂吸附法回收头孢氨苄工艺研究[J]. 离子交换与吸附, 2012, 28(5): 463-468. doi: 10.16026/j.cnki.iea.2012.05.006
5	王新, 马政生, 刘庆芬. 头孢氨苄络合回收工艺[J]. 过程工程学报, 2018, 18(6): 1232-1238. doi: 10.12034/j.issn.1009-606X.218132
6	贾全, 胡利敏, 田洪年, 等. 一种注射用头孢他啶粉针制剂的制备方法:CN，111116611A[P]. 2020-05-08.
7	胡利敏, 贾全, 任峰, 等. 头孢他啶母液冷冻浓缩技术研究与应用[J]. 当代化工, 2020, 49(3): 589-592. doi: 10.13840/j.cnki.cn21-1457/tq.2020.03.019
8	WANG G, SUN T T, SUN Z R, et al.Preparation of copper based metal organic framework materials and its effective adsorptive removal of ceftazidime from aqueous solutions[J]. Applied Surface Science, 2020, 532: 147411. doi: 10.1016/j.apsusc.2020.147411
9	余金橙, 蒋文鸿, 郑海花, 等. 响应面优化草莓汁冷冻浓缩工艺研究[J]. 食品科技, 2020, 45(8): 107-114. doi: 10.13684/j.cnki.spkj.2020.08.018
10	李湘勤, 钟瑞敏, 门戈阳, 等. 局部块冰式两级冷冻浓缩制备高浓度苹果醋[J]. 食品与机械, 2019, 35(9): 187-192. doi: 10.13652/j.issn.1003-5788.2019.09.036
11	ZODE S S, THAKORE S D, BANSAL A K. Effect of process parameters on phase behavior and particle size of aspirin during freeze concentration[J]. Drying Technology, 2020, 38(14): 1891-1903. doi: 10.1080/07373937.2019.1686010
12	贾全, 石春利, 李庆伟, 等. 一种头孢他啶母液的除盐方法及头孢他啶的制备方法: CN，108558908B[P]. 2019-11-29.
13	国家药典委员会.中华人民共和国药典2015年版二部[M]. 北京: 中国医药科技出版社, 2015.

基于响应面设计的头孢他啶母液冷冻浓缩工艺优化

Optimization of the freeze concentration process of ceftazidime mother liquor based on the response surface method

PDF (PC)

赞

可视化

摘要/Abstract

引用本文

使用本文

参考文献 13

相关文章 1

Metrics

本文评价

推荐阅读 0