关键词: 头孢他啶, 冷冻浓缩, 响应面设计, 悬浮结晶冷冻浓缩

Abstract: Using ceftazidime mother liquor as the raw material, we recovered its effective components using suspension freeze concentration technology. Based on single factor test data, taking the recovery rate of ceftazidime as the evaluation index, we used the Box-Behnken response surface method to analyze the three extraction conditions of freezing temperature, freezing time, and stirring rate in three levels respectively to optimize the extraction conditions. The optimum recovery conditions of ceftazidime were as follows: freezing temperature -7 ℃, freezing time 3 h, stirring rate 20 r/min. Results show that the recovery of ceftazidime under these conditions was 93.15%.Combined with the actual production situation, the optimized suspension freeze concentration process is stable and can shed light on the follow-up study of ceftazidime.

Key words: ceftazidime, freeze concentration, response surface method, suspension crystallization freeze concentration