山东科学 ›› 2018, Vol. 31 ›› Issue (6): 18-23.doi: 10.3976/j.issn.1002-4026.2018.06.003

• 药理与毒理 • 上一篇    下一篇

痛利舒颗粒治疗急性痛风性关节炎的实验研究

王平1,2,孙铁锋1,国锦3,焦园园4,刘瑾1,赵渤年1,高燕1   

  1. 1.山东省中医药研究院,山东 济南 250014;2.天津大学精密测试技术及仪器国家重点实验室, 天津 300072;
    3.山东中医药大学,山东 济南 250014;4.天津中医药大学,天津 301600
  • 收稿日期:2018-06-01 出版日期:2018-12-20 发布日期:2018-12-20
  • 作者简介:王平(1974—),女,研究员,硕士研究生导师,研究方向为中药药理。Tel:0531-82949847;E-mail:wangpingjinan@163.com
  • 基金资助:

    山东省重大科技创新工程( 2018CXGC1310,2017CXGC1306,2016ZDJS07A23) ; 山东省中医药科技发展计划(2015-171);山东省自然科学基金(ZR2015HM061);山东省中医药发展计划( 2013Z002-5);山东省五级中医药师承计划

Experimental study on treating acute gouty arthritis with Tonglishu Granule

WANG Ping1,2, SUN Tie-feng1, GUO Jin3, JIAO Yuan-yuan4, LIU Jin 1, ZHAO Bo-nian1,GAO Yan1   

  1. 1.Shandong Academy of Traditional Chinese Medicine,Jinan 250014,China;2 State Key Laboratory of Precision Measurement
     Technology and Instruments,Tianjin University, Tianjin 300072, China; 3.Shandong university of Traditional Chinese
    Medicine,Jinan 250014,China;4.Tianjin university of Traditional Chinese Medicine,Tianjin 301600,China
  • Received:2018-06-01 Online:2018-12-20 Published:2018-12-20

摘要:

通过对痛利舒颗粒的相关药理学研究,评价其对急性痛风性关节炎的治疗作用。建立尿酸钠致急性痛风性关节炎大鼠模型,给予痛利舒颗粒3.24、6.48、12.96 g/kg,考察对踝关节肿胀程度的改善情况;采用热板法测定小鼠痛阈值,给予痛利舒颗粒4.68、9.36、18.72 g/kg,评价其镇痛作用效果;建立巴豆油致小鼠耳廓肿胀模型,给予痛利舒颗粒4.68、9.36、18.72 g/kg,观察其抗炎作用的效果。结果显示,痛利舒颗粒可以改善大鼠踝关节肿胀程度和降低炎症因子TNFα、IL6含量,提高热板法所测的小鼠的痛阈值,具有一定的镇痛作用,亦对巴豆油所致小鼠耳廓肿胀有一定的抗炎作用。

关键词: 急性痛风性关节炎, 热板法, 痛利舒颗粒, 大鼠模型, 耳肿胀

Abstract:

Through pharmacological study on Tonglishu Granule, its therapeutic effects on acute gouty arthritis were evaluated. A rat model of acute gouty arthritis induced by sodium urate was established. Tonglishu Granules were given 3.24,6.48 ,12.96 g/kg respectively to investigate the improvement of ankle swelling degree; The pain threshold of mice was determined by hot plate method, and Tonglishu Granules were given 4.68,9.36,18.72 g/kg to evaluate the painrelieving effect; To establish a model for auricle swelling in mice induced by croton oil, Tonglishu Granules were given 4.68, 9.36, 18.72 g/kg to observe its antiinflammatory effect. The results showed that Tonglishu Granule could improve the degree of ankle joint swelling in rats and reduce the levels of inflammatory factors TNFα and IL6, and improve the pain threshold of mice measured by hot plate method, which had certain analgesic effect. Tonglishu Granule also had certain antiinflammatory effect on croton oilinduced ear swelling in mice.

Key words: Tonglishu Granule, hot plate method, acute gouty arthritis, ear swelling, rat model

中图分类号: 

  • R285.5