关键词: 波谱学, 波谱特征, 头孢孟多酯钠, 结构确证

Abstract:

A method was established for the chemical structure determination of cefamandole nafate by analytical instruments. The elemental analyzer was used to analyze the elemental composition of cefamandole nafate, and nuclear magnetic resonance, mass spectrometry, infrared spectrometry and ultraviolet spectrometry were adopted to analyze the chemical structure of cefamandole nafate. The chemical structure of cefamandole nafate was confirmed to be sodium 7-D-[(2-hydroxy-2phenylacetyl)amino]3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. This method is accurate and practical, which can provide a comprehensive reference for the structural identification of cefamandole nafate.

Key words: structural identification, spectroscopic characteristics, spectroscopy, cefamandole nafate