肌小节组装研究进展

doi:10.3976/j.issn.1002-4026.2017.02.005

摘要/Abstract

摘要：

肌小节是横纹肌的基本功能单位，是由肌动蛋白、肌球蛋白和各种相关蛋白质组装而成的高度有序的结构。在肌小节组装过程中，Z带、M带以及一系列相关蛋白的正确组装是维持肌肉运动的关键，研究肌小节组成蛋白的折叠和组装机制对于了解肌肉疾病的病因和进行有针对性地治疗非常重要。本文综述了肌小节中的主要组分以及组装过程的研究进展，认为目前仍对肌小节骨架的装配、收缩复合体的功能及肌小节组装相关分子伴侣与疾病的关系等的相关研究不够深入。因此，未来还需从肌球蛋白结合蛋白、肌联蛋白、分子伴侣等与疾病的关系方面开展进一步的研究，为肌肉相关疾病的治疗寻找新的思路和解决办法。

关键词: 组装, 肌肉蛋白, 肌小节, 肌肉蛋白, 分子伴侣, 肌小节, 分子伴侣, 组装

Abstract:

As the basic contractile unit of striated muscles, sarcomere has a highly ordered structure, which was assembled by Actin, Myosin, and a variety of related proteins. During the assembling process, the correcting assembly of Z belt, M belt, and a series of associated proteins is essential for maintaining movement of muscles, so the study on the mechanism of folding and assembling of sarcomere composition protein is very important for understanding the causes of muscle disease and carrying out targeted therapy. In this paper, the research progress of sarcomere primary components and sarcomere assembling process was reviewed. It was considered that the present studies on sarcomere skeleton assembly, the function of the sarcomere contractile complex, and the relationship between the chaperones and muscle diseases were not deep enough. Therefore, in the future, more studies should be developed on the relationship between Myosin binding protein, Titin, molecular chaperones, and diseases, to find new ideas and solutions to the treatment of muscle related diseases.

Key words: sarcomere, assembling, molecular chaperones, assembling, molecular chaperones, muscle protein, sarcomere, muscle protein

中图分类号:

Q445

侯彩平,韩利文,侯海荣,王希敏,张姗姗,张轩铭,王雪,李晓彬，田青平,何秋霞,刘可春. 肌小节组装研究进展[J]. 山东科学, 2017, 30(2): 25-36.

HOU Cai-ping, HAN Li-wen, HOU Hai-rong, WANG Xi-min, ZHANG Shan-shan,ZHANG Xuan-ming, WANG Xue, LI Xiao-bin, TIAN Qing-ping, HE Qiu-xia, LIU Ke-chun. The research progress of sarcomere assembly[J]. SHANDONG SCIENCE, 2017, 30(2): 25-36.

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