关键词: 葡萄糖酸钙, 真空冷却结晶, 结晶温度, 转速

Abstract: With calcium gluconate as the research object, a vacuum cooling crystallization experiment was performed to investigate the effects of time, temperature, stirring speed, and vacuum degree on the vacuum cooling crystallization of calcium gluconate. Results show that the factors affecting the crystallization rate of calcium gluconate are listed in the order of desceding degree of impact as vacuum degree, crystallization temperature, and stirring speed, among which the vacuum degree is a significant factor with P<0.05. The optimal process conditions for vacuum cooling crystallization of calcium gluconate are as follows: crystallization temperature is 50 °C, vacuum degree is 0.095 MPa, and stirring speed is 100 r/min. These results provide theoretical basis for technology and device development of calcium gluconate vacuum flash continuous evaporation crystallization.

Key words: calcium gluconate, vacuum cooling crystallization；crystallization temperature;stiring speed